{"type":"trials","record":{"id":93311,"source_id":"clinicaltrials-gov","external_id":"NCT03723902","title":"The Effect of Strength Training and Protein Supplementation in Old Pre-frail Individuals","brief_summary":"The aim of this study is to investigate the effects of a lower-body strength training regime combined with protein supplementation in pre-frail elderly individuals. Participants are randomized to a group performing three weekly sessions of heavy-load strength training for 10 weeks and receiving daily protein supplementation, or a non-training, non-supplemented control group. The endpoints are changes in body composition, the relative changes in different compartments of the quadriceps femoris muscles, and the relationships between changes in muscle mass, muscle thickness, strength, and functional capacity. The investigators hypothesize that 10 weeks of heavy load strength training and protein supplementation will elicit improvements in muscle mass, strength, and functional performance. Moreover, it is hypothesized that improvements in strength will correlate with the improvements in functional performance.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Norwegian School of Sport Sciences","enrollment":22,"countries":["Norway"],"start_date":"2015-07-01","completion_date":"2015-12-21","last_update_date":"2019-03-14","source_url":"https://clinicaltrials.gov/study/NCT03723902","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T05:35:08.159429+00:00","last_seen_at":"2026-09-25T05:35:07.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"75 Years","comparator":"Control","organization":"Norwegian School of Sport Sciences","interventions":["Heavy-load strength training","Protein supplementation"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Muscle strength of m. Quadriceps Femoris — Change from baseline at 10 weks","Muscle strength of m. quadriceps femoris — Change from baseline at 10 weeks","Leg lean mass — Change from baseline at 10 weeks","Total lean mass — Change from baseline at 10 weeks","Fat mass — Change from baseline at 10 weeks","Bone mineral density — Change from baseline at 10 weeks","m. Vastus Lateralis thickness — Change from baseline at 10 weeks","m. Rectus Femoris thickness — Change from baseline at 10 weeks","m. Vastus Intermedius thickness — Change from baseline at 10 weeks","m. Vastus Medialis thickness — Change from baseline at 10 weeks","Isometric knee extension rate of force development (RFD max) — Change from baseline at 10 weeks","Isometric knee extension force at 100 ms — Change from baseline at 10 weeks","Habitual gait velocity — Change from baseline at 10 weeks","Five times chair-rise performance — Change from baseline at 10 weeks","Stair climbing — Change from baseline at 10 weeks","Diet assessment — Change from baseline at 10 weeks"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Aging","Heavy-load strength training","Protein supplementation"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: strength training.","quality_checked_at":"2026-09-25T05:35:12.977559+00:00","duplicate_cluster_key":"id:nct03723902","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-07-01 to 2015-12-21","comparator":"Control","confidence":"structured-source","population":"ALL · 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T05:35:07.560Z","intervention":["Heavy-load strength training","Protein supplementation"],"participants":22,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Muscle strength of m. Quadriceps Femoris — Change from baseline at 10 weks","Muscle strength of m. quadriceps femoris — Change from baseline at 10 weeks","Leg lean mass — Change from baseline at 10 weeks","Total lean mass — Change from baseline at 10 weeks","Fat mass — Change from baseline at 10 weeks","Bone mineral density — Change from baseline at 10 weeks","m. Vastus Lateralis thickness — Change from baseline at 10 weeks","m. Rectus Femoris thickness — Change from baseline at 10 weeks","m. Vastus Intermedius thickness — Change from baseline at 10 weeks","m. Vastus Medialis thickness — Change from baseline at 10 weeks","Isometric knee extension rate of force development (RFD max) — Change from baseline at 10 weeks","Isometric knee extension force at 100 ms — Change from baseline at 10 weeks","Habitual gait velocity — Change from baseline at 10 weeks","Five times chair-rise performance — Change from baseline at 10 weeks","Stair climbing — Change from baseline at 10 weeks","Diet assessment — Change from baseline at 10 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: strength training.","Abstract contains controlled term: strength training.","Source terminology contains: strength training.","Title supplies longevity context: frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/93311","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}