{"type":"trials","record":{"id":93317,"source_id":"clinicaltrials-gov","external_id":"NCT01890382","title":"Protein Intake and Resistance Training in Aging","brief_summary":"Resistance training combined with protein or amino acids supplementation has been shown to be promising for mitigating age-related disabilities and comorbidities. Randomized controlled trials supporting this possibility are still scarce. These series of clinical trials aim to investigate the chronic effects of different strategies of protein and derivatives supplementation in association with resistance training on selected health-related parameters in pre-frail and frail elderly.This is a 16-month, double-blind, randomized, placebo-controlled, parallel-group clinical trial involving a series of investigations. Participants will be divided into nine groups, allowing the assessement of the effects of (1) isolated leucine supplementation; (2) protein source (whey vs. soy); (3) combination of whey protein and creatine; and (4) sexual dimorphism to the response of protein intake plus resistance training (men vs. women). All participants will undergo a supervised, resistance training program.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Sao Paulo","enrollment":200,"countries":["Brazil"],"start_date":"2015-10-01","completion_date":"2017-08-30","last_update_date":"2019-02-15","source_url":"https://clinicaltrials.gov/study/NCT01890382","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T05:35:08.159429+00:00","last_seen_at":"2026-09-25T05:35:07.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":"Control","organization":"University of Sao Paulo","interventions":["Whey protein","whey plus creatine","leucine supplementation","soy protein","creatine","placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["lean mass — 4 months","muscle function — 4 months","bone mass — 4 months","insulin sensitivity — 4 months","health related-quality of life — 4 months"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","source_has_results":false},"controlled_terms":["Frail Elderly Syndrome","Whey protein","whey plus creatine","leucine supplementation","soy protein","creatine","placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: resistance training.","quality_checked_at":"2026-09-25T05:35:12.977559+00:00","duplicate_cluster_key":"id:nct01890382","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-10-01 to 2017-08-30","comparator":"Control","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T05:35:07.561Z","intervention":["Whey protein","whey plus creatine","leucine supplementation","soy protein","creatine","placebo"],"participants":200,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["lean mass — 4 months","muscle function — 4 months","bone mass — 4 months","insulin sensitivity — 4 months","health related-quality of life — 4 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/93317","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}