{"type":"trials","record":{"id":93356,"source_id":"clinicaltrials-gov","external_id":"NCT02593084","title":"Resistance Training to Optimize Health in Pre-frail Older Adults","brief_summary":"Exercise programs, particularly resistance training programs using weights or resistance bands, can help improve or maintain mobility and function in older adults, preserve independent living, and improve quality of life. This study will examine the safety and feasibility of a novel, higher intensity resistance training program in older adults, and compare the effects with standard care, lower intensity training. It is anticipated that both programs will be safe and feasible, but higher-intensity training will lead to greater improvements in quality of life, mobility and strength, which are part of the physical phenotype definition of frailty and markers of mobility disability.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"McMaster University","enrollment":36,"countries":["Canada"],"start_date":"2016-01-01","completion_date":"2017-09-01","last_update_date":"2018-04-18","source_url":"https://clinicaltrials.gov/study/NCT02593084","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T05:35:08.159429+00:00","last_seen_at":"2026-09-25T05:35:07.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":"Lower Intensity Resistance Training","organization":"McMaster University","interventions":["Higher Intensity Resistance Training","Lower Intensity Resistance Training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Occurrence of adverse events — Entire duration of the intervention (12 weeks)","Attendance rate — Entire duration of the intervention (12 weeks)","Attrition rate — Entire duration of the intervention (12 weeks)","Timed Up and Go Test — 0, 12, 20 weeks","Short Physical Performance Battery — 0, 12, 20 weeks","Berg Balance Scale — 0, 12, 20 weeks","Activities-Specific Balance Confidence scale — 0, 12, 20 weeks","Muscle strength — 0, 12, 20 weeks","Short Form-36 — 0, 12, 20 weeks","Caregiver Burden Interview Short Form — 0, 12, 20 weeks","Healthcare Utilization Questionnaires — 0, 12, 20 weeks","Peripheral Quantitative Computed Tomography analysis of muscle and bone quality — 0, 12, 20 weeks","EQ-5D-5L — 0, 12, 20 weeks"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","source_has_results":false},"controlled_terms":["Frail Elderly","Higher Intensity Resistance Training","Lower Intensity Resistance Training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: resistance training.","quality_checked_at":"2026-09-25T05:35:12.977559+00:00","duplicate_cluster_key":"id:nct02593084","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-01-01 to 2017-09-01","comparator":"Lower Intensity Resistance Training","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T05:35:07.566Z","intervention":["Higher Intensity Resistance Training","Lower Intensity Resistance Training"],"participants":36,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Occurrence of adverse events — Entire duration of the intervention (12 weeks)","Attendance rate — Entire duration of the intervention (12 weeks)","Attrition rate — Entire duration of the intervention (12 weeks)","Timed Up and Go Test — 0, 12, 20 weeks","Short Physical Performance Battery — 0, 12, 20 weeks","Berg Balance Scale — 0, 12, 20 weeks","Activities-Specific Balance Confidence scale — 0, 12, 20 weeks","Muscle strength — 0, 12, 20 weeks","Short Form-36 — 0, 12, 20 weeks","Caregiver Burden Interview Short Form — 0, 12, 20 weeks","Healthcare Utilization Questionnaires — 0, 12, 20 weeks","Peripheral Quantitative Computed Tomography analysis of muscle and bone quality — 0, 12, 20 weeks","EQ-5D-5L — 0, 12, 20 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training.","Source terminology contains: resistance training.","Title supplies longevity context: frail, older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/93356","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}