{"type":"trials","record":{"id":93359,"source_id":"clinicaltrials-gov","external_id":"NCT02968888","title":"Anabolic Effects of Whey and Casein After Strength Training in Young and Elderly","brief_summary":"The aim of this study is to investigate the acute anabolic effects of native whey, whey protein concentrate 80 (WPC-80) and milk after a bout of strength training in young and elderly. The investigators hypothesize that native whey will give a greater stimulation of muscle protein synthesis and intracellular anabolic signaling than WPC-80, and that WPC-80 will give a stronger stimulus than milk.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Norwegian School of Sport Sciences","enrollment":43,"countries":["Norway"],"start_date":"2014-08-01","completion_date":"2017-05-01","last_update_date":"2018-04-10","source_url":"https://clinicaltrials.gov/study/NCT02968888","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T05:35:08.159429+00:00","last_seen_at":"2026-09-25T05:35:07.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":"Milk","organization":"Norwegian School of Sport Sciences","interventions":["Strength training","Milk 1%","Whey protein concentrate 80","Native whey"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Mixed muscle fractional synthetic rate — Three to one hours prior to a bout of strength training and protein consumption","Mixed muscle fractional synthetic rate — One to five hours after a bout of strength training and protein consumption","Mixed muscle fractional synthetic rate — From three to five hours after a bout of strength training and protein consump…","Mixed muscle fractional breakdown rate — From three to five hours after a bout of strength training and protein consump…","Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline — 30 min before, 1, 2.…","Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline — 30 min before,…","Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) chang…","Intracellular translocation of forkhead box O3 (FOXO3a) change from baseline — 30 min before, 1, 2.5 and 5 hours after…","Intracellular translocation of muscle RING-finger protein-1 (Murf-1) change from baseline — 30 min before, 1, 2.5 and 5…","Intracellular translocation of Atrogin1 change from baseline — 30 min before, 1, 2.5 and 5 hours after training and pro…","Ubiquitin — 30 min before, 1, 2.5 and 5 hours after training and protein intake","Plasma amino acid concentration — 180 and 60 min before, and 45, 60, 75, 120, 160, 180, 200, 220 and 300 min after trai…","Muscle force generating capacity change from baseline — 15 min before, 15 and 300 min after, and 24 hours after trainin…","Plasma glucose — 180 and 60 min before, and 45, 60, 75, 120, 160, 180, 200, 220 and 300 min after training and protein…","Plasma insulin — 180 and 60 min before, and 45, 60, 75, 120, 160, 180, 200, 220 and 300 min after training and protein…","Serum urea — 180 and 60 min before, and 60, 10, 180 and 300 min after training and protein intake","Serum ureic acid — 180 and 60 min before, and 60, 10, 180 and 300 min after training and protein intake","Serum creatine kinase — 180 and 60 min before, and 60, 10, 180 and 300 min after training and protein intake","Change in ATP-binding cassette transporter (ABCA1) messenger ribonucleic acid (mRNA) — 1 hour after training and protei…","Change in ABCA1 mRNA — 5 hous after training and protein intake"],"design_description":"RANDOMIZED · CROSSOVER · BASIC SCIENCE · TRIPLE","source_has_results":false},"controlled_terms":["Healthy","Young","Elderly","Strength training","Milk 1%","Whey protein concentrate 80","Native whey"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: strength training.","quality_checked_at":"2026-09-25T05:35:12.977559+00:00","duplicate_cluster_key":"id:nct02968888","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2014-08-01 to 2017-05-01","comparator":"Milk","confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T05:35:07.567Z","intervention":["Strength training","Milk 1%","Whey protein concentrate 80","Native whey"],"participants":43,"study_design":"RANDOMIZED · CROSSOVER · BASIC SCIENCE · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Mixed muscle fractional synthetic rate — Three to one hours prior to a bout of strength training and protein consumption","Mixed muscle fractional synthetic rate — One to five hours after a bout of strength training and protein consumption","Mixed muscle fractional synthetic rate — From three to five hours after a bout of strength training and protein consump…","Mixed muscle fractional breakdown rate — From three to five hours after a bout of strength training and protein consump…","Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline — 30 min before, 1, 2.…","Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline — 30 min before,…","Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) chang…","Intracellular translocation of forkhead box O3 (FOXO3a) change from baseline — 30 min before, 1, 2.5 and 5 hours after…","Intracellular translocation of muscle RING-finger protein-1 (Murf-1) change from baseline — 30 min before, 1, 2.5 and 5…","Intracellular translocation of Atrogin1 change from baseline — 30 min before, 1, 2.5 and 5 hours after training and pro…","Ubiquitin — 30 min before, 1, 2.5 and 5 hours after training and protein intake","Plasma amino acid concentration — 180 and 60 min before, and 45, 60, 75, 120, 160, 180, 200, 220 and 300 min after trai…","Muscle force generating capacity change from baseline — 15 min before, 15 and 300 min after, and 24 hours after trainin…","Plasma glucose — 180 and 60 min before, and 45, 60, 75, 120, 160, 180, 200, 220 and 300 min after training and protein…","Plasma insulin — 180 and 60 min before, and 45, 60, 75, 120, 160, 180, 200, 220 and 300 min after training and protein…","Serum urea — 180 and 60 min before, and 60, 10, 180 and 300 min after training and protein intake","Serum ureic acid — 180 and 60 min before, and 60, 10, 180 and 300 min after training and protein intake","Serum creatine kinase — 180 and 60 min before, and 60, 10, 180 and 300 min after training and protein intake","Change in ATP-binding cassette transporter (ABCA1) messenger ribonucleic acid (mRNA) — 1 hour after training and protei…","Change in ABCA1 mRNA — 5 hous after training and protein intake"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: strength training.","Abstract contains controlled term: strength training.","Source terminology contains: strength training.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/93359","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}