Continuously updated topic dossier

Epigenetic clocks

Biological-age measurements based on DNA methylation and related signals.

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Automated evidence frame

When does a change in a biological-age measure predict a meaningful change in health?

How this is generated

Current evidence state

Multiple clocks correlate with age and outcomes, but interchangeability and intervention interpretation are unresolved.

Known limits

Assay, tissue, training population, calibration, causality, and surrogate-endpoint validity can materially change results.

Regulatory context

A clock result is not a diagnosis, validated treatment outcome, or approval signal by itself.

Building the latest evidence view…