Research record

Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1

Preprint — not peer reviewed published by bioRxiv (Cold Spring Harbor Laboratory), indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.

Plain-language guide

Five questions to ask about this record

What this is
preprint record from bioRxiv (Cold Spring Harbor Laboratory).
Why it may matter
It matched a longevity topic and may show how that evidence area is developing.
Evidence
Automated topic match 100%; this is not a medical rating.
Main limitation
One research record does not prove safety, effectiveness, or usefulness for an individual.
What changed
Source metadata was published or refreshed June 25, 2022.
Where to verify
Open the primary source below for methods, population, results, and limitations.
Published
June 25, 2022
Journal
bioRxiv (Cold Spring Harbor Laboratory)
Authors
Talita C. Conte, Gilberto Duran-Bishop, Zakaria Orfi, Inès Mokhtari, Alyson Deprez, Marie‐Pier Roussel, Isabelle Côté, Ornella Pellerito, Damien Maggiorani, Basma Benabdallah, Séverine Leclerc, Lara Feulner, Jean Mathieu, Cynthia Gagnon, Grégor Andelfinger, Christian M. Beausejour, Serge McGraw, Élise Duchesne, Nicolas A. Dumont
DOI
10.1101/2022.06.22.497227
Evidence class
preprint
Record status
published
Match confidence
100%
Citations
1
Source feed
OpenAlex
Automated source synopsis

Preprint — not peer reviewed published by bioRxiv (Cold Spring Harbor Laboratory), indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.

Evidence snapshot

What the source actually supports

Evidence stage
Preprint — not peer reviewed
Study design
preprint
Evidence population
Not established from reusable metadata
Participants
Not reported
Population
Not reported
Duration
Not reported
Intervention
Comparator
Not reported
Outcomes measured
Reported result
No reusable finding-level result is available in this record.

Main limitationThis record has not completed peer review, and the reusable source metadata does not support a finding-level summary.

Safety and approvalThis index record does not establish safety, effectiveness, dose, or suitability for any person. A publication record is not a regulatory approval or treatment recommendation.

Source supportBibliographic citation metadata and controlled indexing terms only. Read the linked source for methods and results.

Evidence stage · preprintThis describes the study type, not whether an intervention is safe or effective.
Lab or animalHuman studyRandomized trialEvidence synthesis
Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Senescence-associated secretory phenotype · 100%Title contains controlled topic terminology. Source terminology contains a controlled topic term. Title supplies ageing or longevity context.
  • Senolytics · 100%Title contains controlled topic terminology. Source terminology contains a controlled topic term. Title supplies ageing or longevity context.
  • Stem cells · 100%Title contains controlled topic terminology. Source terminology contains a controlled topic term. Title supplies ageing or longevity context.

Automated source check 70% · update recency 50%. These figures help sort records; they are not medical ratings.

BibTeX · RIS

senescence saspsenolyticsstem cells
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