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An automatically updated log of new research, trial status changes, regulatory notices, corrections, retractions, and publication-quality changes.
151research changes in 30 days
95trials changes in 30 days
0regulatory changes in 30 days
0integrity changes in 30 days
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- Publication-quality status changed · September 16, 2026trials
Metformin in Elderly Patients With Type 2 Diabetes and Muscle Strength, Muscle Mass, and Physical Function: Positive or Negative Correlation?
- Publication-quality status changed · September 16, 2026trials
METformin and FINGER Intervention to Prevent Cognitive Impairment and Disability in Older Adults at Risk for Dementia
- Publication-quality status changed · September 16, 2026trials
Creating Stem Cells From a Progeria Patient's Blood to Test Candidate Treatments in the Lab
- Publication-quality status changed · September 16, 2026trials
The Role of Sirolimus in Preventing Functional Decline in Older Adults
- Publication-quality status changed · September 16, 2026trials
RESTOR: PK/PD mTORi Inhibition in Older Adults
- Publication-quality status changed · September 16, 2026trials
Therapeutic Synergy of Probiotic Augmented Conventional Antidiabetic Pharmacotherapy in Gestational Diabetes Mellitus
- Publication-quality status changed · September 16, 2026trials
BIOANCIENT: Cohort of Centenarians in Navarra (1926-1927)
- Publication-quality status changed · September 16, 2026trials
BIOANCIENT_EX: Effects of a Physical Exercise Program in Centenarians of the BIOANCIENT Cohort: A Randomized Clinical Trial.
- Publication-quality status changed · September 16, 2026trials
The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity
- Publication-quality status changed · September 16, 2026trials
Preventing Falls in Older Adults With Cognitive Frailty
- Publication-quality status changed · September 16, 2026trials
Protein Supplementation in Elderly With Sarcopenic Obesity Undergoing Caloric Restriction and Exercise
- Publication-quality status changed · September 16, 2026trials
Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women
- Publication-quality status changed · September 16, 2026trials
Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation
- Publication-quality status changed · September 16, 2026trials
Focusing on the Menopausal Transition to Improve Mid-Life Women's Health
- Publication-quality status changed · September 16, 2026trials
VITAL: Vaccination, Immunity, Time-restricted Eating, Aging and Lifestyle
- Publication-quality status changed · September 16, 2026trials
Everolimus Aging Study
- Publication-quality status changed · September 16, 2026trials
Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors
- Publication-quality status changed · September 16, 2026trials
Metformin and Molecular Aging in Prediabetes
- Publication-quality status changed · September 16, 2026trials
A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes
- Publication-quality status changed · September 16, 2026trials
CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy
- Publication-quality status changed · September 16, 2026research
Discovery of a quinoline-based senomorphic agent for the treatment of chronic kidney disease.
- Publication-quality status changed · September 16, 2026research
Luteolin is associated with alleviation of cigarette smoke-induced cellular senescence and inflammation in mice involving the CREB/c-Fos/NQO1 pathway.
- Publication-quality status changed · September 16, 2026research
Mitochondrial dysfunction as a key mediator of endplate chondrocyte senescence: emerging insights and targeted interventions.
- Publication-quality status changed · September 16, 2026research
6-Shogaol attenuates liver fibrosis by driving hepatic stellate cell senescence through the cGAS-STING-NF-κB axis.
- Publication-quality status changed · September 16, 2026research
Mechanisms of Hematopoietic Stem Cell Aging and Emerging Rejuvenation Strategies.
- Publication-quality status changed · September 16, 2026research
PRMT5 lactylation mediates SIRT6-dependent DNA damage and senescence in benzene-induced hematotoxicity.
- Publication-quality status changed · September 16, 2026research
Low expression of PDGFR-β impairs the blood-brain barrier and accelerates cellular aging in the hippocampal region.
- Publication-quality status changed · September 16, 2026research
Aging as cross-hallmark obstruction amplification: A sheaf-theoretic model of repair closure, senescence, inflammation, and regenerative failure.
- Publication-quality status changed · September 16, 2026research
Targeting the hallmarks of ageing: Pharmacological challenges and breakthroughs in CRISPR delivery systems and future prospects.
- Publication-quality status changed · September 16, 2026research
Systemic recalibration and epigenetic resetting as complementary strategies in ageing biology.
- Publication-quality status changed · September 16, 2026research
The nutrition-sleep-circadian axis in age-related neurodegeneration: Cellular mechanisms, metabolic dysfunction, and neuroprotective interventions.
- Publication-quality status changed · September 16, 2026research
Aging of mesenchymal stem cells in bone aging: Mechanisms, impact, and therapeutic perspectives.
- Publication-quality status changed · September 16, 2026research
Beyond Diabetes: Continuous Glucose Monitoring as a Candidate Precision Tool for Cardiovascular Prevention and Healthy Longevity-A Hypothesis-Generating Narrative Review.
- Publication-quality status changed · September 16, 2026research
Aging preserves mTORC1 but attenuates JNK-SMAD2L signaling sensitivity to passive stretch-induced tension development in isolated mouse skeletal muscle.
- Publication-quality status changed · September 16, 2026research
Lung function after randomization to metformin, lifestyle intervention or placebo in the Diabetes Prevention Program Outcomes Study (DPPOS).
- Publication-quality status changed · September 16, 2026research
Association of sleep duration and hypertension in older adults: a cross-sectional study.
- Publication-quality status changed · September 16, 2026research
Oxidative stress, aging, metabolism, SIRT1, and the gut microbiota: the neurocardiac basis of cognitive loss.
- Publication-quality status changed · September 16, 2026research
Geroprotective Effects of Drugs Modulating Metabolic Pathways: Perspectives of Pharmacology in Anti-Aging Therapy.
- Publication-quality status changed · September 16, 2026research
A dual-engineered chondrocyte-targeting tetrahedral DNA-based nanoparticle for improved delivery of metformin and alleviation in osteoarthritis.
- Publication-quality status changed · September 16, 2026research
Exercise attenuates atherosclerosis by inhibiting eWAT aging via targeting SIRT1/pyruvate carboxylase pathway.
- Publication-quality status changed · September 16, 2026research
Punicalagin alleviates senile osteoporosis by inhibiting the senescence of bone mesenchymal stem cells via NRF2/HO-1 pathway.
- Publication-quality status changed · September 16, 2026research
Recombinant human collagen XVII protects epidermal stem cells from blue light-induced photoaging by downregulating the Notch pathway.
- New research record · September 16, 2026research
Crocin I delays cellular senescence potentially via modulating SIRT1/PKM2 expression to improve lactate homeostasis in vitro .
- New research record · September 16, 2026research
Rapamycin targetome mining identifies RBBP7 as a druggable epigenetic vulnerability in hepatocellular carcinoma.
- Publication-quality status changed · September 16, 2026research
Clearance of p16-positive cardiac cells improves age-related cardiac remodeling in mice.
- Publication-quality status changed · September 16, 2026research
LSD1-mediated demethylation of the DNA damage response factor ATM promotes senescence and organ aging
- Publication-quality status changed · September 16, 2026research
Neutrophil Senescence Induced by Tumor-Derived HMGB1 Promotes Hepatocellular Carcinoma Progression through Neutrophil Extracellular Trap-Mediated Suppression of CD8<sup>+</sup> T Cell Immunity.
- Publication-quality status changed · September 16, 2026research
Late-life semaglutide treatment slows ageing and extends lifespan in female mice.
- Publication-quality status changed · September 16, 2026research
Blocking PD-L2 prevents senescent cell accumulation and age-related dysfunction.
- Publication-quality status changed · September 16, 2026research
The vicious cycle of SASP and inflammaging promotes aging and age-related diseases.
- Publication-quality status changed · September 16, 2026research
Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK.
- Publication-quality status changed · September 16, 2026research
Obstructive sleep apnea risk is associated with a diminished cognitive profile: findings from the Canadian longitudinal study on aging
- Publication-quality status changed · September 16, 2026research
Epigenetic clocks and accelerated biological aging in people living with HIV: Emerging mechanisms and clinical implications.
- Publication-quality status changed · September 16, 2026research
Co-Delivery of Sustained Release Chondroitinase ABC-37 With Human iPSC-Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke.
- Publication-quality status changed · September 16, 2026research
Synergistic nanosenolytic therapy reverses age-related dry eye disease by targeting cellular senescence and oxidative stress.
- Publication-quality status changed · September 16, 2026research
Punicalagin alleviates senile osteoporosis by inhibiting the senescence of bone mesenchymal stem cells via NRF2/HO-1 pathway.
- Publication-quality status changed · September 16, 2026research
Recombinant human collagen XVII protects epidermal stem cells from blue light-induced photoaging by downregulating the Notch pathway.
- New research record · September 16, 2026research
Interstitial fluid rejuvenation through young-donor plasma exchange in cognitively impaired patients: a pilot safety and feasibility study.
- New research record · September 16, 2026research
Minimally processed, human-grade diet alters canine epigenetic ageing: Results from a pilot study.
- New research record · September 16, 2026research
Brain aging clocks: From methodological advances to cellular mechanisms.
- New research record · September 16, 2026research
Accelerated aging in schizophrenia: integrating epigenetic clocks, telomere dynamics, senescence-associated secretory phenotype, and oxidative stress.
- New research record · September 16, 2026research
Dimensions of early life adversity and accelerated biological aging in adolescents: an examination of fear-related mechanisms.
- New research record · September 16, 2026research
The effect of sleep status on all-cause mortality and premature death among middle-aged and older adults: A national cohort study.
- New research record · September 16, 2026research
Sleep-related Alzheimer's disease vulnerability in aging: A muscle-metabolic perspective.
- New research record · September 16, 2026research
Brain health across the lifespan and the impact of nutrition, exercise, microbiota, and sleep.
- New research record · September 16, 2026research
When sleep daily rhythm meets the eye: sleep regularity as a behavioral signal of ocular aging.
- New research record · September 16, 2026research
Sleep regularity and age-related eye diseases: prospective analyses with retinal imaging and multimorbidity assessment in the UK Biobank.
- New research record · September 16, 2026research
The associations of trouble sleeping, biological age acceleration with depressive symptoms: Evidence from three cohorts.
- New research record · September 16, 2026research
Transcriptomics reveals species-specific adaptive strategies to calorie restriction in two Argopecten scallops with distinct lifespans.
- New research record · September 16, 2026research
Impact of caloric restriction on biological aging: insights from a composite biomarker index in older adults.
- New research record · September 16, 2026research
Rationale and Design of Traditional and Adaptive Calorie Restriction and Time-Restricted Eating Interventions Used in the Dietary Approaches to Longevity and Health (DiAL Health) Pilot Trial.
- New research record · September 16, 2026research
Duration of Caloric Restriction Modulates Brain Redox Adaptation and Frailty During Aging.
- New research record · September 16, 2026research
A simplified intermittent fasting regimen robustly extends C. elegans lifespan without FUdR or antibiotic confounds.
- New research record · September 16, 2026research
Sirtuins as Molecular Mediators of Caloric Restriction in the Pancreas: Implications for β-Cell Function, Metabolism, and Longevity.
- New research record · September 16, 2026research
Exercise modality and subsequent musculoskeletal medical expenditures among middle-aged and older adults: A population-based longitudinal study.
- New research record · September 16, 2026research
Exercise modalities for overall and domain-specific balance performance in older adults: A systematic review and Bayesian network meta-analysis.
- New research record · September 16, 2026research
Nutritional Support With Or Without Exercise for Older Adults With GLIM-Compatible Malnutrition: A Meta-Analysis of Randomized Controlled Trials.
- New research record · September 16, 2026research
Estimated Cardiorespiratory Fitness and Incident Cardiometabolic Multimorbidity in Older Adults: A Prospective Cohort Study.
- New research record · September 16, 2026research
Hearing healthy: physical activity moderates the association between age-related hearing loss and brain volume.
- Publication-quality status changed · September 16, 2026research
A Systems Pharmacology Model of Aging Identifies Optimal Combination Therapies With Secondary Benefits on Weight Loss and Metabolic Health.
- New research record · September 16, 2026research
The GLP-1-Mitochondria Axis in Metabolic Aging.
- New research record · September 16, 2026research
Corrigendum to "The multifaceted role of GLP-1 in metabolic disorders, chronic inflammation, and aging: Mechanisms and therapeutic potential" [Metabolism 2026 May: 178: 156547].
- New research record · September 16, 2026research
Semaglutide exerts anti-pulmonary fibrosis effects by inhibiting cellular senescence through activation of the Sirt1/HSF1/HSPs pathway.
- New research record · September 16, 2026research
GLP-1 receptor agonists in older people with type 2 diabetes: safety evidence from the real world.
- New research record · September 16, 2026research
Methionine-supplemented longevity diet increases growth hormone, GLP-1, and FGF21; reduces frailty; and promotes healthspan.
- New research record · September 16, 2026research
Chronological lifespan extension evaluation-driven comparative study of five Indian dietary spices for geroprotective action via phytochemical profiling, bioactivity screening and network pharmacology in Saccharomyces cerevisiae.
- New research record · September 16, 2026research
Metformin alleviates aging-associated periodontitis via NRF2-mediated restoration of the IRE1α dependent unfolded protein response.
- New research record · September 16, 2026research
Lifestyle and Metformin Interventions and Risk of Multimorbidity in Adults With Prediabetes.
- New research record · September 16, 2026research
Metformin Enhances Antioxidant Defenses and Limits Lipid Peroxidation Through the Modulation of Nrf2/KEAP1 Pathway in Hippocampal Neurons Exposed to Amyloid-β Oligomers.
- New research record · September 16, 2026research
Metformin in Neurodegenerative Diseases: Mechanisms and Therapeutic Implications.
- New research record · September 16, 2026research
Metformin at the convergence of aging and longevity.
- New research record · September 16, 2026research
Metformin Inhibits Cardiac Fibroblast Differentiation by Promoting Fatty Acid β-Oxidation: Implications for Age-Associated Cardiac Fibrosis.
- New research record · September 16, 2026research
Metformin: A Promising Candidate for Slowing the Progression of Cardiovascular Aging.
- New research record · September 16, 2026research
Concept and connotation of the geroprotective and anti-aging effects of metformin: From AMPK activation to SASP suppression.
- New research record · September 16, 2026research
A Randomized Clinical Trial of Metformin to Reduce Frailty in Older Adults with Glucose Intolerance.
- New research record · September 16, 2026research
p38 MAPK and MDT-15 mediate SKN-1-dependent metformin-induced protection against mitis group streptococci in Caenorhabditis elegans.
- New research record · September 16, 2026research
Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice.
- New research record · September 16, 2026research
S2P-modified PLGA bifunctional nanodrug: inhibiting vascular senescence and foam cell formation for atherosclerosis treatment.
- New research record · September 16, 2026research
Corrigendum to "Metformin prevents mandibular bone loss in a mouse model of accelerated aging by correcting dysregulated AMPK-mTOR signaling and osteoclast differentiation" [J Orthop Transl 46 (2024) 129-142].
- New research record · September 16, 2026research
Reductive death is averted by a conserved de novo lipogenic switch.