Research record

Study protocol for a multiarm, randomized controlled trial to determine the effectiveness of community-based frailty rehabilitation to improve physical function in older adults: The OPTIMAL Fitness Trial.

Randomized human study published by PLoS ONE, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.

Plain-language guide

Five questions to ask about this record

What this is
randomized-human record from PLoS ONE.
Why it may matter
It matched a longevity topic and may show how that evidence area is developing.
Evidence
Automated topic match 75%; this is not a medical rating.
Main limitation
One research record does not prove safety, effectiveness, or usefulness for an individual.
What changed
Source metadata was published or refreshed January 1, 2026.
Where to verify
Open the primary source below for methods, population, results, and limitations.
Published
January 1, 2026
Journal
PLoS ONE
Authors
Alexandra Papaioannou, Courtney Kennedy, Justin Lee, Patricia Hewston, Caitlin McArthur, Shyam Maharaj, Jonathan Adachi, Pauline Boulos, Raja Bobba, Alexander Rabinovich, Brian McKenna, Lisa Palubiski, Dee Mangin, Lehana Thabane, Sharon Marr, Sharon Kaasalainen, Jean-Éric Tarride, Olga Theou, David Armstrong, Ahmed Negm, Michael Noseworthy, Kenneth Rockwood, Lisa Dolovich, Hajar Abu Alrob, Genevieve Hladysh, Karen Thompson, George Ioannidis
DOI
10.1371/journal.pone.0343338
Evidence class
randomized-human
Record status
published
Match confidence
75%
Source feed
Directory of Open Access Journals
Automated source synopsis

Randomized human study published by PLoS ONE, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.

Evidence snapshot

What the source actually supports

Evidence stage
Randomized human study
Study design
Open-access journal article
Evidence population
Human evidence
Participants
Not reported
Population
Not reported
Duration
Not reported
Intervention
Comparator
Not reported
Outcomes measured
Reported result
No reusable finding-level result is available in this record.

Main limitationBibliographic metadata identifies the record but does not provide enough reusable detail to summarize its population, comparison, findings, or effect size.

Safety and approvalThis index record does not establish safety, effectiveness, dose, or suitability for any person. A publication record is not a regulatory approval or treatment recommendation.

Source supportBibliographic citation metadata and controlled indexing terms only. Read the linked source for methods and results.

Evidence stage · randomized-humanThis describes the study type, not whether an intervention is safe or effective.
Lab or animalHuman studyRandomized trialEvidence synthesis
Why this record appears here · 75% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Frailty · 75%Title contains controlled topic terminology. Title supplies ageing or longevity context.

Automated source check 90% · update recency 85%. These figures help sort records; they are not medical ratings.

BibTeX · RIS

frailty
Read the original source →Export JSON