Research record

Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease With Pulmonary Hypertension and Frailty

Preclinical research published by Circulation, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.

Plain-language guide

Five questions to ask about this record

What this is
preclinical record from Circulation.
Why it may matter
It matched a longevity topic and may show how that evidence area is developing.
Evidence
Automated topic match 75%; this is not a medical rating.
Main limitation
One research record does not prove safety, effectiveness, or usefulness for an individual.
What changed
Source metadata was published or refreshed March 3, 2022.
Where to verify
Open the primary source below for methods, population, results, and limitations.
Published
March 3, 2022
Journal
Circulation
Authors
Ana Victoria Lechuga-Vieco, Ana Latorre-Pellicer, Enrique Calvo, Carlos Torroja, Juan Pellico, Rebeca Acín-Pérez, María Luisa García-Gil, Arnoldo Santos, Navratan Bagwan, Elena Bonzon-Kulichenko, Ricardo Magni, Marina Benito, Raquel Justo-Méndez, Anna Katharina Simon, Fátima Sánchez-Cabo, Jesús Vázquez, Jesús Ruíz-Cabello, José Antonio Enríquez
DOI
10.1161/circulationaha.121.056286
Evidence class
preclinical
Record status
published
Match confidence
75%
Citations
35
Source feed
OpenAlex
Automated source synopsis

Preclinical research published by Circulation, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.

Evidence snapshot

What the source actually supports

Evidence stage
Preclinical research
Study design
article
Evidence population
Preclinical (laboratory or animal research)
Participants
Not reported
Population
Not reported
Duration
Not reported
Intervention
Comparator
Not reported
Outcomes measured
Reported result
No reusable finding-level result is available in this record.

Main limitationPreclinical findings may not apply to people; the reusable source metadata does not provide enough detail to assess the result.

Safety and approvalThis index record does not establish safety, effectiveness, dose, or suitability for any person. A publication record is not a regulatory approval or treatment recommendation.

Source supportBibliographic citation metadata and controlled indexing terms only. Read the linked source for methods and results.

Evidence stage · preclinicalThis describes the study type, not whether an intervention is safe or effective.
Lab or animalHuman studyRandomized trialEvidence synthesis
Why this record appears here · 75% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Frailty · 75%Title contains controlled topic terminology. Title supplies ageing or longevity context.

Automated source check 70% · update recency 50%. These figures help sort records; they are not medical ratings.

BibTeX · RIS

frailty
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