Research record

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Preclinical research published by Nature Medicine, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.

Plain-language guide

Five questions to ask about this record

What this is
preclinical record from Nature Medicine.
Why it may matter
It matched a longevity topic and may show how that evidence area is developing.
Evidence
Automated topic match 65%; this is not a medical rating.
Main limitation
One research record does not prove safety, effectiveness, or usefulness for an individual.
What changed
Source metadata was published or refreshed December 14, 2015.
Where to verify
Open the primary source below for methods, population, results, and limitations.
Published
December 14, 2015
Journal
Nature Medicine
Authors
Jianhui Chang, Yingying Wang, Lijian Shao, Remi-Martin Laberge, Marco Demaria, Judith Campisi, Janakiraman Krishnamurthy, Norman E. Sharpless, Sheng Ding, Wei Feng, Yi Luo, Xiaoyan Wang, Nükhet Aykin‐Burns, Kimberly J. Krager, Usha Ponnappan, Martin Hauer‐Jensen, Aimin Meng, Daohong Zhou
DOI
10.1038/nm.4010
Evidence class
preclinical
Record status
published
Match confidence
65%
Citations
1836
Source feed
OpenAlex
Automated source synopsis

Preclinical research published by Nature Medicine, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.

Evidence snapshot

What the source actually supports

Evidence stage
Preclinical research
Study design
article
Evidence population
Preclinical (laboratory or animal research)
Participants
Not reported
Population
Not reported
Duration
Not reported
Intervention
Comparator
Not reported
Outcomes measured
Reported result
No reusable finding-level result is available in this record.

Main limitationPreclinical findings may not apply to people; the reusable source metadata does not provide enough detail to assess the result.

Safety and approvalThis index record does not establish safety, effectiveness, dose, or suitability for any person. A publication record is not a regulatory approval or treatment recommendation.

Source supportBibliographic citation metadata and controlled indexing terms only. Read the linked source for methods and results.

Evidence stage · preclinicalThis describes the study type, not whether an intervention is safe or effective.
Lab or animalHuman studyRandomized trialEvidence synthesis
Why this record appears here · 65% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Blood stem-cell ageing · 65%Title contains controlled topic terminology. Source terminology supplies ageing or longevity context.
  • Senolytics · 65%Title contains controlled topic terminology. Source terminology supplies ageing or longevity context.

Automated source check 70% · update recency 35%. These figures help sort records; they are not medical ratings.

BibTeX · RIS

hematopoietic stem cell agingsenolytics
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