Research record

Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.

Human study published by Circulation, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.

Plain-language guide

Five questions to ask about this record

What this is
human-study record from Circulation.
Why it may matter
It matched a longevity topic and may show how that evidence area is developing.
Evidence
Automated topic match 60%; this is not a medical rating.
Main limitation
One research record does not prove safety, effectiveness, or usefulness for an individual.
What changed
Source metadata was published or refreshed February 26, 2019.
Where to verify
Open the primary source below for methods, population, results, and limitations.
Published
February 26, 2019
Journal
Circulation
Authors
Meera V Singh, Sivareddy Kotla, Nhat-Tu Le, Kyung Ae Ko, Kyung-Sun Heo, Yin Wang, Yuka Fujii, Hang Thi Vu, Elena McBeath, Tamlyn N Thomas, Young Jin Gi, Yunting Tao, Jan L Medina, Jack Taunton, Nancy Carson, Vikram Dogra, Marvin M Doyley, Alicia Tyrell, Wang Lu, Xing Qiu, Nicole E Stirpe, Kathleen J Gates, Christine Hurley, Keigi Fujiwara, Sanjay B Maggirwar, Giovanni Schifitto, Jun-Ichi Abe
DOI
10.1161/CIRCULATIONAHA.118.036232
Evidence class
human-study
Record status
published
Match confidence
60%
Source feed
PubMed
Automated source synopsis

Human study published by Circulation, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.

Evidence snapshot

What the source actually supports

Evidence stage
Human study
Study design
Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Evidence population
Human evidence
Participants
Not reported
Population
Not reported
Duration
Not reported
Intervention
Comparator
Not reported
Outcomes measured
Reported result
No reusable finding-level result is available in this record.

Main limitationBibliographic metadata identifies the record but does not provide enough reusable detail to summarize its population, comparison, findings, or effect size.

Safety and approvalThis index record does not establish safety, effectiveness, dose, or suitability for any person. A publication record is not a regulatory approval or treatment recommendation.

Source supportBibliographic citation metadata and controlled indexing terms only. Read the linked source for methods and results.

Evidence stage · human-studyThis describes the study type, not whether an intervention is safe or effective.
Lab or animalHuman studyRandomized trialEvidence synthesis
Why this record appears here · 60% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Senolytics · 60%Source terminology contains a controlled topic term. Source terminology supplies ageing or longevity context.

Automated source check 95% · update recency 50%. These figures help sort records; they are not medical ratings.

BibTeX · RIS

senolytics
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