A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.
What the source actually supports
- Evidence stage
- Phase 1, Phase 2
- Study design
- RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE
- Evidence population
- Human clinical study registration
- Participants
- 100
- Population
- ALL · 40 Years to 85 Years
- Duration
- 2021-05-18 to 2025-06-01
- Intervention
- Fisetin; Losartan; Placebo - Losartan; Placebo Fisetin
- Comparator
- Active Fisetin and Losartan Placebo; Fisetin Placebo and Active Losartan; Control
- Outcomes measured
- Incidence of Treatment-Emergent Adverse Events — Adverse events will be collected from the date of BMAC injection to 12…; Morphological and Quantitative Magnetic Resonance Imaging (MRI) — 32 days - 3 months prior to injection, 6 months post…; Evaluation of patient reported outcome (PRO) for quality of life — within 3 months of injection, 32 days post baseline,…; Evaluation of patient reported outcome (PRO) for knee functions (WOMAC) — within 3 months of injection, 32 days post ba…; Evaluation of patient reported outcome (PRO) for knee functions (Tegner) — within 3 months of injection, 32 days post b…; Evaluation of patient reported outcome (PRO) for knee functions (IKDC) — within 3 months of injection, 32 days post bas…; Patient-Reported Outcome Questionnaires — Screening, weekly post 1st study drug dose (pre-injection), weekly post injec…; Change in muscle strength of the study knee — 32 days - 3 months prior to injection, 6 months post injection, 12 months…; Change in physical function of the Study Knee (LEK) — 32 days - 3 months prior to injection, 6 months post injection, 1…; Change in physical function of the Study Knee (Stair Test) — 32 days - 3 months prior to injection, 6 months post injec…; Change in physical function of the Study Knee (fast 40-meter walk) — 32 days - 3 months prior to injection, 6 months po…; Change in physical function of the Study Knee (TUG) — 32 days - 3 months prior to injection, 6 months post injection, 1…; Change in physical function of the Study Knee (6-minute walk test) — 32 days - 3 months prior to injection, 6 months po…; Change in associate biomarkers as compared to placebo in peripheral blood plasma/serum — screening, 14 days post-inject…; Change in CTX-II as compared to placebo in urine — 32 days post baseline, 6 months post injection, 12 months post injec…; Change in levels of senescent PBMCS (total and specific PBMC subsets such as T-Cells) — screening, 14 days post-injecti…; Change in synovial fluid content — 32 days post baseline, 6 months post injection, 12 months post injection; Characterization of Bone Marrow Derived Aspirate Concentrate cell content prior to injection — 32 days post baseline; Characterization of Bone Marrow Derived plasma biomarkers prior to injection — 32 days post baseline; Change in time to conversion to alternative treatment — Subjects may receive alternative treatment at any point during…
- Reported result
- No reusable finding-level result is available in this record.
Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.
Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.
Source supportStructured registry protocol metadata; no finding-level conclusion is generated.
Registration and recruitment status do not establish safety, efficacy, or regulatory approval.
Why this record appears here · 100% topic match
The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.
- Senolytics · 100%Title contains controlled topic terminology. Summary contains controlled topic terminology.
Automated source check 100% · update recency 65%. These figures help sort records; they are not medical ratings.