Clinical trial registry record

Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain

A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Recruiting.
Evidence
Registered phase 2 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated January 8, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT06837857
Last registry update
January 8, 2026
Status
Recruiting
Phase
Phase 2
Sponsor
Mayo Clinic
Enrollment
200
Countries
United States
Match confidence
80%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 2
Study design
RANDOMIZED · PARALLEL · OTHER · QUADRUPLE
Evidence population
Human clinical study registration
Participants
200
Population
ALL · 65 Years
Duration
2025-04-16 to 2029-12-31
Intervention
Opioid; Opioid Placebo
Comparator
Placebo Group
Outcomes measured
White matter fractional anisotropy (FA) of corpus callosum — Baseline, 12 months; White matter fractional anisotropy (FA) of other axonal tracts — Baseline, 12 months; Gray matter cortical thickness — Baseline, 12 months; Subcortical gray matter volumes — Baseline, 12 months; Mayo Preclinical Alzheimer's disease Cognitive Composite (Mayo-PACC) Global-z — Baseline, 6 weeks, 12 months; Trailmaking Test A — Baseline, 6 weeks, 12 months; Digit span memory test — Baseline, 6 weeks, 12 months; Mayo Test Drive — Baseline, 6 weeks, 6 month web based, 1 year
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 2A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 80% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Chronic pain and ageing · 80%Title contains controlled topic terminology. Title supplies ageing or longevity context.

Automated source check 100% · update recency 85%. These figures help sort records; they are not medical ratings.

chronic pain aging
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