Clinical trial registry record

Rapamycin - Effects on Alzheimer's and Cognitive Health

A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Active Not Recruiting.
Evidence
Registered phase 2 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated June 9, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT04629495
Last registry update
June 9, 2026
Status
Active Not Recruiting
Phase
Phase 2
Sponsor
The University of Texas Health Science Center at San Antonio
Enrollment
40
Countries
United States
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 2
Study design
RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE
Evidence population
Human clinical study registration
Participants
40
Population
ALL · 55 Years to 89 Years
Duration
2021-08-11 to 2027-03-05
Intervention
Rapamycin; Placebo
Comparator
RAPA (rapamycin) treatment group; Placebo group
Outcomes measured
Number of adverse events — Baseline to 12 months; Change in glucose level — Baseline to 12 months; Change in albumin — Baseline to 12 months; Change in carbon dioxide or bicarbonate (CO2) — Baseline to 12 months; Change in calcium — Baseline to 12 months; Central nervous system penetration of rapamycin — Baseline and 12 months; Change in Cognition using preclinical Alzheimer's Cognitive Composite 5 (PACC5) — Baseline to 12 months; Change in Cognition using Clinical Dementia Rating Scale sum of Boxes (CDR-SOB) — Baseline to 12 months; Change in Functional status — Baseline to 12 months; Change in Neuropsychiatric symptoms — Baseline to 12 months; Change in Gait Speed — Baseline to 12 months; Change in Grip Strength — Baseline to 12 months; Change in CSF amyloid beta — Baseline to 12 months; Change in cerebral glucose metabolism — Baseline to 12 months; Change in Brain Volumetry — Baseline to 12 months
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 2A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Rapamycin · 100%Title contains controlled topic terminology. Summary contains controlled topic terminology. Source terminology contains a controlled topic term. Summary supplies ageing or longevity context.

Automated source check 100% · update recency 100%. These figures help sort records; they are not medical ratings.