Clinical trial registry record

Efficacy and Safety of Brolucizumab 6mg in a Treat and Extend Regimen in Patients With Neovascular Age-Related Macular Degeneration (nAMD) With Prior Anti-VEGF Exposure (PEREGRINE)

A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Withdrawn. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Withdrawn.
Evidence
Registered phase 3 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated September 23, 2021.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT04697953
Last registry update
September 23, 2021
Status
Withdrawn
Phase
Phase 3
Sponsor
Novartis Pharmaceuticals
Enrollment
0
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Withdrawn. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 3
Study design
NA · SINGLE GROUP · TREATMENT · NONE
Evidence population
Human clinical study registration
Participants
0
Population
ALL · 50 Years
Duration
2021-05-31 to 2025-05-31
Intervention
brolucizumab
Comparator
Not reported
Outcomes measured
The proportion (%) of patients switched from aflibercept 2 mg to brolucizumab 6mg that were able to successfully extend…; Mean maximum interval (number of weeks) of patients at week 104 — Up to 104 weeks; The % of patients switched from aflibercept 2 mg to brolucizumab 6mg that were able to extend their dosing interval at…; The % of patients switched from aflibercept 2 mg to brolucizumab 6mg that were able to maintain or extend their dosing…; Mean interval (number of weeks) of patients after switch reached at any given time point at week 52 and 104 — up to 104…; Mean change in Best Corrected Visual Acuity (BCVA) Early Treatment Diabetic Retinopathy Study (EDTRS letters) from base…; The % of patients with a change in BCVA (EDTRS letters) of 5, 10, 15 letters or more from baseline to week 52, and 104…; The % of patients with any intraretinal fluid (IRF) and/or subretinal fluid (SRF) at baseline, weeks 52, and 104 — up t…; Incidence of ocular (e.g., intraocular infection) and non-ocular adverse events, vital signs up to week 52, and 104 — u…; Mean change from baseline in central subfield foveal thickness (CSFT) — at weeks 52, 104; The % of patients with pigment epithelial detachment (PED) — at baseline, weeks 52, 104
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 3A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Vision ageing · 100%Title contains controlled topic terminology. Source terminology contains a controlled topic term. Title supplies ageing or longevity context.

Automated source check 100% · update recency 50%. These figures help sort records; they are not medical ratings.