Clinical trial registry record

Efficacy and Safety of Two Treatment Regimens of 0.5 mg Ranibizumab Intravitreal Injections Guided by Functional and/or Anatomical Criteria, in Patients With Neovascular Age-related Macular Degeneration

A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Completed.
Evidence
Registered phase 3 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated August 14, 2017.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT01780935
Last registry update
August 14, 2017
Status
Completed
Phase
Phase 3
Sponsor
Novartis Pharmaceuticals
Enrollment
671
Countries
Argentina, Austria, Canada, Colombia, Czechia, Finland, France, Germany, Greece, Guatemala, Hungary, Ireland, Italy, Lithuania, Mexico, Netherlands, Panama, Portugal, Slovakia, Spain, Sweden, Switzerland, Turkey (Türkiye), United Kingdom
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 3
Study design
RANDOMIZED · PARALLEL · TREATMENT · DOUBLE
Evidence population
Human clinical study registration
Participants
671
Population
ALL · 50 Years
Duration
2013-06-03 to 2015-07-09
Intervention
Ranibizumab
Comparator
Not reported
Outcomes measured
Average Best-corrected Visual Acuity (BCVA) (Letters) Change up to Month 12 — up to Month 12; Change From Baseline in Visual Acuity (Letters) of the Study Eye up to Month 12 — up to Month 12; Gain of Equal or More Than 1, 5, 10, or 15 Letters in Visual Acuity of the Study Eye From Baseline, at Month 12 and 24…; Loss of Less Than 5, 10, and 15 Letters in Visual Acuity in the Study Eye From Baseline, at Month 12 and 24 — Baseline…; Visual Acuity of 73 Letters or More in the Study Eye at Month 12 and 24 — Month 12 and 24; Average Visual Acuity Change From Month 3 to Month 4 Through Month 24 in the Study Eye — Month 3 to Month 24; Average Visual Acuity Change From Baseline to Month 1 Through Month 12 and 24 in the Study Eye — Baseline to Month 12 a…; Change From Baseline in Central Sub-Field Thickness (CSFT) and Central Sub-Field Volume (CSFV) of the Study Eye Over Ti…; Dry Retina in the Study Eye on OCT at Month 12 and 24 — Month 12 and 24; Change From Baseline in Lesion Size and Morphology Based on Fluorescein Angiography at Month 12 and 24 — Baseline to Mo…; Treatment Patterns Over Time in Both Treatment Arms — Baseline to Month 12 and 24; Change From Baseline in the National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) Scores Over Time — Bas…; Frequency and Severity of Ocular and Non-ocular Adverse Events Over Time — Screening to Month 12 and 24
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 3A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Vision ageing · 100%Title contains controlled topic terminology. Source terminology contains a controlled topic term. Title supplies ageing or longevity context.

Automated source check 100% · update recency 50%. These figures help sort records; they are not medical ratings.