Clinical trial registry record

Randomized Study for Efficacy and Safety of Ranibizumab 0.5mg in Treat-extend and Monthly Regimens in Patients With nAMD

A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Completed.
Evidence
Registered phase 3 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated April 17, 2017.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT01948830
Last registry update
April 17, 2017
Status
Completed
Phase
Phase 3
Sponsor
Novartis Pharmaceuticals
Enrollment
650
Countries
Belgium, Chile, Croatia, Denmark, Egypt, Germany, Hungary, India, Israel, Italy, Portugal, Russia, Slovakia, Slovenia, South Korea, Spain, Switzerland, Turkey (Türkiye), United Kingdom
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 3
Study design
RANDOMIZED · PARALLEL · SUPPORTIVE CARE · SINGLE
Evidence population
Human clinical study registration
Participants
650
Population
ALL · 50 Years
Duration
2013-12-17 to 2015-11-19
Intervention
Ranibizumab 0.5mg
Comparator
Group I ranibizumab 0.5 mg monthly; Group II ranibizumab 0.5 mg TER
Outcomes measured
Change in Best Corrected Visual Acuity (BCVA) From Baseline to Month 12 — Baseline to month 12; Number of Visits Scheduled — From Month1 to Month 11; Change in BCVA From Baseline to Month 12 — Baseline to Month 12; Average BCVA Change From Baseline to Month 12 — Baseline and every month for 12 months; Mean Change in Visual Acuity BCVA (Letters) From Baseline to Month 12 — Baseline and every month for 12 months; Number of Patients With a BCVA Improvement of ≥1, ≥5, ≥10, ≥15, and ≥30 Letters From Baseline to Month 12 — Baseline an…; Number of Patients With Best Corrected Visual Acuity (BCVA) Loss <5, <10, and <15 Letters by Visit — Baseline and every…; Number of Patients With a BCVA Value of ≥ 73 Letters (Approximate 20/40 Snellen Chart Equivalent) at Month 12 — Baselin…; The Mean Number of Treatment Frequency — Month 12; The Average Number of Days Between Injections — Month 12; Percentage of Participants With Fluid Free Macula Over Time up to Month 12 — Month 12; Change in Central Subfield Retinal Thickness (CSFT) Over Time — Month 12; Percentage of Patients With Choroidal Neovascularization (CNV) Leakage Assessed by Fluorescein Angiography (FA) in the…; Change From Baseline in Composite Score of the National Eye Institute-Visual Function Questionnaire-25 (NEI-VFQ-25) — B…
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 3A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Vision ageing · 100%Summary contains controlled topic terminology. Source terminology contains a controlled topic term. Summary supplies ageing or longevity context.

Automated source check 100% · update recency 50%. These figures help sort records; they are not medical ratings.