Clinical trial registry record

TAC-PF, Avastin® in Combination With Photodynamic Therapy to Treat Age Related Macular Degeneration

A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Terminated. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Terminated.
Evidence
Registered phase 2 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated March 24, 2010.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT00464347
Last registry update
March 24, 2010
Status
Terminated
Phase
Phase 2
Sponsor
National Eye Institute (NEI)
Enrollment
100
Countries
United States
Match confidence
60%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Terminated. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 2
Study design
RANDOMIZED · PARALLEL · TREATMENT · SINGLE
Evidence population
Human clinical study registration
Participants
100
Population
ALL · 50 Years
Duration
2007-01-01 to 2007-09-01
Intervention
Avastin; Photodynamic Therapy (PDT); Preservative-Free Triamcinolone Acetonide (TAC-PF)
Comparator
Not reported
Outcomes measured
The mean change in best-corrected ETDRS visual acuity in the study eye from baseline to month 12; Mean and median change in ETDRS BCVA from baseline to months 3, 6, and 24.; Proportion of participants avoiding a loss of ³ 15 letters in ETDRS BCVA by months 3, 6, 12, and 24; Proportion of participants improving by ³ 15 letters in ETDRS BCVA at months 3, 6, 12, and 24.; Proportion of participants who show any improvement in ETDRS BCVA at months 3, 6, 12, and 24.; Mean change in the total lesion area (Disc Areas) from baseline to months 3, 6, 12, and 24.; Mean change in area of CNV (Disc Areas) at months 3, 6, 12, and 24.; Mean change in area of leakage (Disc Areas) at months 3, 6, 12, and 24.; Proportion of classic CNV out of the entire lesion from baseline to months 3, 6, 12, and 24.; Changes in mean excess retinal thickening in the center subfield (i.e., thickness >175 microns) from baseline to months…; Proportion of participants with reduction in retinal thickening in the center subfield (i.e., thickness > 175 microns)…; The overall probability of re-injection (excluding injections precluded for safety concerns) through Month 12.; The mean number of injections by quarter on study following initial induction injections.
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 2A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 60% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Vision ageing · 60%Source terminology contains a controlled topic term. Source terminology supplies ageing or longevity context.

Automated source check 100% · update recency 35%. These figures help sort records; they are not medical ratings.