Clinical trial registry record

Insulin Resistance and Mild Cognitive Impairment (IRMCI) Study

A registered PHASE4 study indexed because it matched monitored longevity research terms. Registry status: Terminated. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Terminated.
Evidence
Registered phase 4 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated January 11, 2023.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT02409238
Last registry update
January 11, 2023
Status
Terminated
Phase
Phase 4
Sponsor
SingHealth Polyclinics
Enrollment
105
Countries
Singapore
Match confidence
90%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE4 study indexed because it matched monitored longevity research terms. Registry status: Terminated. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 4
Study design
RANDOMIZED · PARALLEL · TREATMENT · NONE
Evidence population
Human clinical study registration
Participants
105
Population
ALL · 55 Years
Duration
2015-03-11 to 2019-12-31
Intervention
Metformin; Intensive Lifestyle Intervention; Standard LIfestyle Recommendation
Comparator
Standard Level of Care
Outcomes measured
Primary efficacy endpoint (Cerebral Glucose Metabolic Rate) — 2 years; Primary cognitive endpoint (Neuropsychological Performance) — 2 years; Secondary clinical endpoints Subjective Memory and Cognitive Complaint (SMCC — 2 years; Secondary clinical endpoints Basic Activities of Daily Liver (ADL) — 2 years; Secondary clinical endpoints Cognitive Instrumental Activities of Daily Living Scale — 2 years; Secondary clinical endpoints Global Clinical Dementia Rating Sum of Boxes — 2 years; Secondary clinical endpoints Mini-Mental State Examination — 2 years; Secondary clinical endpoints Montreal Cognitive Assessment scale — 2 years; Secondary adherence endpoints fasting plasma insulin — 2 years; Secondary adherence endpoints Homeostatic Model Assessment (HOMA) — 2 years; Secondary adherence endpoints Lifestyle Intervention (Change in Weight) — 2 years; Secondary adherence endpoints Body Mass Index — 2 years; Secondary adherence endpoints Waist Circumference — 2 years; Secondary adherence endpoints Fasting plasma glucose — 2 years; Secondary adherence endpoints Glycated Hemoglobin (HbA1c) — 2 years; Secondary adherence endpoints Fasting Lipids — 2 years
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 4A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 90% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Metformin · 90%Summary contains controlled topic terminology. Source terminology contains a controlled topic term.

Automated source check 100% · update recency 50%. These figures help sort records; they are not medical ratings.

metformin
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