Clinical trial registry record

Targeting Senescence to Reduce Osteoarthritis Pain and cartilagE Breakdown (ROPE)

A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Withdrawn. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Withdrawn.
Evidence
Registered phase 1, phase 2 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated July 29, 2022.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT04770064
Last registry update
July 29, 2022
Status
Withdrawn
Phase
Phase 1, Phase 2
Sponsor
Austin V Stone
Enrollment
0
Countries
United States
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Withdrawn. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 1, Phase 2
Study design
RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE
Evidence population
Human clinical study registration
Participants
0
Population
ALL · 35 Years to 80 Years
Duration
2023-06-01 to 2024-05-31
Intervention
High-dose/short-duration Fisetin; Low-dose/sustained-duration Fisetin; Oral placebo capsule
Comparator
Placebo
Outcomes measured
Change in markers of liver toxicity — Change between baseline and 3-month follow-up; Change in markers of kidney toxicity — Change between baseline and 3-month follow-up; Change in markers of tumor lysis syndrome — Change between baseline and 3-month follow-up; Pain Visual Analogue Scale (VAS) — Change between baseline and 3-month follow-up; Western Ontario and MacMaster Universities Osteoarthritis Index (WOMAC) — Change between baseline and 3-month follow-up; Five times sit-to-stand test — Change between baseline and 3-month follow-up; Biomarker of cellular senescence (MMP-3) — Change between baseline and 3-month follow-up; Biomarker of cartilage breakdown (CTXII) — Change between baseline and 3-month follow-up
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 1, Phase 2A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Joint and cartilage ageing · 100%Title contains controlled term: osteoarthritis. Abstract contains controlled term: osteoarthritis. Source terminology contains: osteoarthritis. Title supplies longevity context: senescence. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 50%. These figures help sort records; they are not medical ratings.

joint cartilage aging
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