Clinical trial registry record

Oral Metformin for Treatment of ABCA4 Retinopathy

A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Active Not Recruiting.
Evidence
Registered phase 1, phase 2 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated September 24, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT04545736
Last registry update
September 24, 2026
Status
Active Not Recruiting
Phase
Phase 1, Phase 2
Sponsor
National Eye Institute (NEI)
Enrollment
55
Countries
United States
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 1, Phase 2
Study design
NA · SINGLE GROUP · TREATMENT · NONE
Evidence population
Human clinical study registration
Participants
55
Population
ALL · 12 Years to 100 Years
Duration
2020-11-23 to 2029-02-02
Intervention
Metformin hydrochloride
Comparator
Not reported
Outcomes measured
The difference in growth rate of square-root transformed area of EZ band loss (vAreaEZloss) — Pre-treatment, Baseline,…; Proportion of participants with a 30% reduction in growth rate of vAreaEZloss — Pre-treatment, Baseline, Month 24; Number and severity of adverse events — ongoing throughout study; Changes in best corrected visual acuity (BCVA) — Baseline, Month 24; Change in rate of area of atrophy enlargement — Pre-treatment, Baseline, Month 24; Change in perimetry and color fundus photography measurements — Baseline, Month 24
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 1, Phase 2A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Metformin · 100%Title contains controlled topic terminology. Summary contains controlled topic terminology. Source terminology contains a controlled topic term.

Automated source check 100% · update recency 100%. These figures help sort records; they are not medical ratings.

metformin
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