Clinical trial registry record

A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD

A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Recruiting.
Evidence
Registered phase 3 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated September 21, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT06847542
Last registry update
September 21, 2026
Status
Recruiting
Phase
Phase 3
Sponsor
Hoffmann-La Roche
Enrollment
250
Countries
Austria, Czechia, Denmark, France, Germany, Greece, Italy, Poland, South Korea, Spain, Switzerland, Thailand, United Kingdom
Match confidence
60%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 3
Study design
NA · SINGLE GROUP · TREATMENT · NONE
Evidence population
Human clinical study registration
Participants
250
Population
ALL · 50 Years
Duration
2025-11-27 to 2028-11-15
Intervention
Susvimo PDS Implant; Ranibizumab
Comparator
Not reported
Outcomes measured
Change From Baseline in Best Corrected Visual Acuity (BCVA) Score Averaged Over Weeks 68 and 72, as Assessed Using the…; Change From Baseline in BCVA Score Over Time — From baseline up to Week 72; Percentage of Participants Who Lose ≤ 15, ≤ 10, ≤ 5, or Gain ≥ 0 Letters in BCVA Score From Baseline Over Time — From b…; Change From Baseline in Center Point Thickness (CPT) — From baseline up to Week 72; Change From Baseline in Central Subfield Thickness (CST) — From baseline up to Week 72; Proportion of Participants Who do not Undergo Supplemental Treatment With IVT Ranibizumab Before Each Refill-exchange P…; Number of Supplemental Treatments Participants Received in Each Refill Cycle — Up to Week 72; Frequency of Study Visits in Each Refill Cycle — Up to Week 72; Proportion of Participants Who Report Preferring PDS Compared With IVT Ranibizumab Treatment as Measured by the PDS Pat…; Proportion of Participants With Bilateral Disease Who Report Preferring PDS Compared With IVT Ranibizumab Treatment Mea…; Number of Participants With Ocular and Systemic (Non-ocular) Adverse Events (AEs) — Up to approximately 19 months; Number of Participants With Adverse Events of Special Interests (AESIs) and their Severity, Including Ocular AESIs — Up…; Number of Participants With Ocular AESIs and Severity of Ocular AESIs During the Post-operative and Follow-up Period —…; Number of Participants With Adverse Device Effects (ADEs) and Severity of ADEs With PDS — Up to approximately 19 months; Number of Participants With Anticipated Serious Adverse Device Effects (ASADEs) and Severity of ASADEs With PDS — Up to…
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 3A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 60% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Vision ageing · 60%Source terminology contains: age-related macular degeneration. Source terminology supplies longevity context: age-related. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 100%. These figures help sort records; they are not medical ratings.