Clinical trial registry record

The Impact of Cranberries On the Microbiome and the Brain in Healthy Ageing sTudy (COMBAT)

A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Completed.
Evidence
Registered phase not reported study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated September 30, 2020.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT03679533
Last registry update
September 30, 2020
Status
Completed
Phase
Phase not reported
Sponsor
University of East Anglia
Enrollment
60
Countries
United Kingdom
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase not reported
Study design
RANDOMIZED · PARALLEL · PREVENTION · QUADRUPLE
Evidence population
Human clinical study registration
Participants
60
Population
ALL · 50 Years to 80 Years
Duration
2018-10-02 to 2020-05-22
Intervention
Freeze-Dried Cranberry Powder; Placebo
Comparator
Active Cranberry Study Food; Placebo Study Food
Outcomes measured
Gut microflora speciation and metabolism — 12 weeks; Change in volumes of hippocampus and other key brain structures — 12 weeks; Change in cerebrovascular blood flow — 12 weeks; Change in global cognition — 12 weeks; Change in spatial navigation abilities — 12 weeks; Change in executive function and attention — 12 weeks; Change in memory performance — 12 weeks; Change in executive function and attention — 12 Weeks; Change in presence of circulating inflammatory biomarkers (hs-CRP) — 12 weeks; Change in circulating biomarkers of neuronal functioning and cognitive decline (BDNF) — 12 weeks; Change in circulating biomarkers of lipid metabolism (total-, HDL-, LDL-cholesterol) — 12 weeks; Change in circulating biomarkers of lipid metabolism (triglycerides) — 12 weeks; Changes in energy expenditure and sleep — 12 weeks; Genetics related to neurodegenerative disease — Baseline; Biomarkers of gut permability and endotoxemia (LPS) — 12 weeks; Levels of sunlight exposure — Baseline, Follow-up
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase not reportedA trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Microbiome and dysbiosis · 100%Title contains controlled term: microbiome. Abstract contains controlled term: microbiome. Title supplies longevity context: ageing. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 50%. These figures help sort records; they are not medical ratings.

microbiome dysbiosis
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