Clinical trial registry record

Exogenous Ketosis During Bed Rest in Older Adults

A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Completed.
Evidence
Registered phase not reported study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated February 7, 2024.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT05679596
Last registry update
February 7, 2024
Status
Completed
Phase
Phase not reported
Sponsor
McGill University
Enrollment
30
Countries
Canada
Match confidence
80%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase not reported
Study design
RANDOMIZED · PARALLEL · PREVENTION · TRIPLE
Evidence population
Human clinical study registration
Participants
30
Population
ALL · 65 Years to 85 Years
Duration
2023-02-27 to 2023-11-15
Intervention
ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutyrate; carbohydrate-fat placebo (fructose, corn and canola oil 50:50 ratio)
Comparator
Energy matched control (CON)
Outcomes measured
Changes in integrated fractional synthesis rate (%/d) in response to bed rest with and without ketone monoester (KET) s…; Changes in whole body insulin sensitivity in response to bed rest with and without ketone monoester (KET) supplementati…; Changes in whole-body lean mass (kg) in response to bed rest with and without ketone monoester (KET) supplementation —…; Changes in leg lean mass (kg) in response to bed rest with and without ketone monoester (KET) supplementation — Day -3…; Changes in quadriceps muscle volume in response to bed rest with and without ketone monoester (KET) supplementation. —…; Changes in maximal voluntary isometric contraction (N/m) of the knee extensors in response to bed rest with and without…; Changes in handgrip strength (kg) in response to bed rest with and without ketone monoester (KET) supplementation. — Da…; Changes in physical performance (numerical score) as determined by short physical performance battery (SPPB) in respons…; Changes in physical performance (numerical score) as determined by 5-item physical performance test in response to bed…; Changes in cognitive status in response to bed rest with and without ketone monoester (KET) supplementation. — Day 4 an…; Changes in markers of inflammation in systemic circulation in response to bed rest with and without ketone monoester (K…; Changes in muscle mRNA expression of inflammatory regulators will be assessed in response to bed rest with and without…; Changes in skeletal muscle phenotype in response to bed rest with and without ketone monoester (KET) supplementation. —…; Changes in skeletal muscle fiber size in response to bed rest with and without ketone monoester (KET) supplementation.…; Changes in mitochondrial content in response to bed rest with and without ketone monoester (KET) supplementation. — Day…; Changes in mitochondrial respiration in response to bed rest with and without ketone monoester (KET) supplementation. —…; Changes in mitochondrial calcium retention capacity (marker of mitochondrial propensity to trigger apoptosis) in respon…; Changes in mitochondrial reactive oxygen species (ROS) production in response to bed rest with and without ketone monoe…; Changes in mitochondrial time to the permeability transition pore opening (marker of mitochondrial propensity to trigge…; Changes in the phosphorylation status of anabolic signaling molecules modulating muscle protein synthesis (MPS) in resp…
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase not reportedA trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 80% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Ketogenic diets · 80%Title contains controlled term: ketosis. Title supplies longevity context: older adult. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 65%. These figures help sort records; they are not medical ratings.

ketogenic diets
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