Clinical trial registry record

Hyperemesis Gravidarum Risk Reduction With Metformin

A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Recruiting.
Evidence
Registered phase 1, phase 2 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated July 22, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT07129473
Last registry update
July 22, 2026
Status
Recruiting
Phase
Phase 1, Phase 2
Sponsor
University of Southern California
Enrollment
224
Countries
United States
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 1, Phase 2
Study design
NON RANDOMIZED · PARALLEL · PREVENTION · NONE
Evidence population
Human clinical study registration
Participants
224
Population
FEMALE · 18 Years to 49 Years
Duration
2026-07-13 to 2031-03-01
Intervention
Metformin Extended Release Oral Tablet
Comparator
Survey/Comparator Arm
Outcomes measured
Adherence to Escalating Doses of Metformin-XR — Baseline to 8 weeks after treatment initiation; Tolerability and Safety of Metformin-XR — Baseline through treatment completion (up to 12 months after maintenance dose…; Hyperemesis Gravidarum (HG) Recurrence and Severity — From confirmed pregnancy through 12 weeks of gestation; Pregnancy & Neonatal Outcomes: Incidence of Pregnancy Complications — From confirmed pregnancy through delivery; Pregnancy & Neonatal Outcomes: Delivery Characteristics — At delivery; Pregnancy & Neonatal Outcomes: Assessment of Peripartum Events — From confirmed pregnancy to 6 months postpartum; Pregnancy & Neonatal Outcomes: Maternal Postpartum Depression — From birth to 6 months postpartum; Pregnancy & Neonatal Outcomes: Maternal Postpartum Anxiety — From birth to 6 months postpartum; Pregnancy & Neonatal Outcomes: Maternal Postpartum Quality of Life — From birth to 6 months postpartum; Pregnancy & Neonatal Outcomes: Neonatal Health Status — At delivery; Pregnancy & Neonatal Outcomes: Child Developmental Status — From birth to 6 months postpartum (with optional follow up…; Indicators of Metformin Response: Genetic Factors — Once at baseline; Indicators of Metformin Response: Circulating Biomarker Levels — Once at baseline, once when participant reaches highes…; Indicators of Metformin Response: Demographic Characteristics — At baseline
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 1, Phase 2A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Metformin · 100%Title contains controlled topic terminology. Summary contains controlled topic terminology. Source terminology contains a controlled topic term.

Automated source check 100% · update recency 100%. These figures help sort records; they are not medical ratings.

metformin
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