Clinical trial registry record

Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults

A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Recruiting.
Evidence
Registered phase not reported study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated February 20, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT07144527
Last registry update
February 20, 2026
Status
Recruiting
Phase
Phase not reported
Sponsor
Scott Silveira
Enrollment
40
Countries
United States
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase not reported
Study design
RANDOMIZED · CROSSOVER · BASIC SCIENCE · QUADRUPLE
Evidence population
Human clinical study registration
Participants
40
Population
ALL · 60 Years to 80 Years
Duration
2026-02-21 to 2027-01-01
Intervention
NMN, betaine, low-dose hydrogen peroxide (EGA); Nicotinamide Mononucleotide (NMN); Placebo
Comparator
Not reported
Outcomes measured
Time to Fatigue During Constant Work Rate Cycle Ergometry (tLIM). — Measured at the beginning and end of each 4-week in…; Peak Oxygen Uptake (VO2max) — Measured at the beginning and end of each 4-week intervention period.; Lactate Threshold — Measured at the beginning and end of each 4-week intervention period.; Anaerobic Work Capacity — Measured at the beginning and end of each 4-week intervention period.; Critical Power — Measured at the beginning and end of each 4-week intervention period.; Circulating NAD+ and Related Metabolites — Measured at the beginning and end of each 4-week intervention period.
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase not reportedA trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Exercise · 100%Title contains controlled term: exercise. Abstract contains controlled term: exercise. Source terminology contains: exercise. Title supplies longevity context: older adult. Study type is explicitly identified as INTERVENTIONAL.
  • NAD metabolism · 100%Title contains controlled term: nicotinamide mononucleotide. Abstract contains controlled term: nad+, nicotinamide mononucleotide. Source terminology contains: nicotinamide mononucleotide, nmn. Title supplies longevity context: older adult. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 85%. These figures help sort records; they are not medical ratings.

exercisenad metabolism
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