A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.
What the source actually supports
- Evidence stage
- Phase 2
- Study design
- RANDOMIZED · PARALLEL · PREVENTION · QUADRUPLE
- Evidence population
- Human clinical study registration
- Participants
- 512
- Population
- ALL · 18 Years to 45 Years
- Duration
- 2024-05-06 to 2029-12-01
- Intervention
- Metformin; Placebo
- Comparator
- Placebo
- Outcomes measured
- KOOS Pain Score — Average of 12 and 24 months; Modified MOAKS Cartilage Score — 24 months; KOOS Pain — baseline, 3 months, 6 months, 9 months, 12 months, 18 months, 24 months; KOOS Symptoms — baseline, 3 months, 6 months, 9 months, 12 months, 18 months, 24 months; KOOS Activities of Daily Living (ADL) — baseline, 3 months, 6 months, 9 months, 12 months, 18 months, 24 months; KOOS Sport and Recreation Function — baseline, 3 months, 6 months, 9 months, 12 months, 18 months, 24 months; KOOS Quality of Life — baseline, 3 months, 6 months, 9 months, 12 months, 18 months, 24 months; Marx Activity Rating Scale — baseline, 12 months, 24 months; Work Productivity and Activity Impairment (WPAI) — baseline, 3 months, 6 months, 9 months, 12 months, 18 months, 24 mon…; EuroQoL Score — baseline, 3 months, 6 months, 9 months, 12 months, 18 months, 24 months; Tampa Scale of Kinesiophobia Score — baseline, 3 months, 6 months, 9 months, 12 months, 18 months, 24 months; MHI-5 Score — baseline, 3 months, 6 months, 9 months, 12 months, 18 months, 24 months; Joint Space Narrowing Over Time — baseline, 12 months, 24 months; Cartilage composition assessed with T1rho, T2 — baseline, 12 months, 24 months; Severity of Synovitis on Contrast MRI — baseline, 12 months; Knee Range of Motion — 12 and 24 months; 3D Gait Biomechanics — 12 and 24 months; Isokinetic knee flexion/extension strength at 60º/sec — 12 and 24 months; 10m Habitual Walking Speed — 12 and 24 months; Single Leg Hop Test — 12 and 24 months
- Reported result
- No reusable finding-level result is available in this record.
Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.
Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.
Source supportStructured registry protocol metadata; no finding-level conclusion is generated.
Registration and recruitment status do not establish safety, efficacy, or regulatory approval.
Why this record appears here · 90% topic match
The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.
- Metformin · 90%Summary contains controlled topic terminology. Source terminology contains a controlled topic term.
Automated source check 100% · update recency 65%. These figures help sort records; they are not medical ratings.