Clinical trial registry record

Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With nAMD

A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Enrolling By Invitation. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Enrolling By Invitation.
Evidence
Registered phase 2 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated August 5, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT05210803
Last registry update
August 5, 2026
Status
Enrolling By Invitation
Phase
Phase 2
Sponsor
AbbVie
Enrollment
116
Countries
United States
Match confidence
60%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Enrolling By Invitation. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 2
Study design
NON RANDOMIZED · PARALLEL · TREATMENT · NONE
Evidence population
Human clinical study registration
Participants
116
Population
ALL
Duration
2021-12-20 to 2031-07-01
Intervention
Standard of Care; Ranibizumab
Comparator
Not reported
Outcomes measured
Incidences of ocular Adverse Events and any Serious Adverse Events — 5 years inclusive of parent study; Incidences of non-ocular Adverse Events and any Adverse Events of Special Interest — 5 years inclusive of parent study; Mean change from baseline (ie, prior to ABBV-RGX-314 administration in the parent study) in BCVA based on ETDRS score i…; Mean change from baseline (ie, prior to ABBV-RGX-314 administration in the parent study) in CRT as measured by SD-OCT i…; Mean number of supplemental anti-VEGF injections through years 2, 3, 4 and 5 — 5 years inclusive of parent study; Mean number of supplemental anti-VEGF injections in years 2, 3, 4, and 5 — 5 years inclusive of parent study; Mean supplemental anti-VEGF injection annualized rate through years 2, 3, 4, and 5 — 5 years inclusive of parent study; Mean supplemental anti-VEGF injection annualized rate in years 2, 3, 4, and 5 — 5 years inclusive of parent study; Mean number of retina specialist visits attended for nAMD through years 2, 3, 4, and 5 — 5 years inclusive of parent st…; Mean number of retina specialist visits attended for nAMD in years 2, 3, 4, and 5 — 5 years inclusive of parent study
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 2A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 60% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Vision ageing · 60%Source terminology contains: age-related macular degeneration. Source terminology supplies longevity context: age-related. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 100%. These figures help sort records; they are not medical ratings.