Clinical trial registry record

A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Active Not Recruiting.
Evidence
Registered phase not reported study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated June 1, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT06161584
Last registry update
June 1, 2026
Status
Active Not Recruiting
Phase
Phase not reported
Sponsor
Apellis Pharmaceuticals, Inc.
Enrollment
300
Countries
United States
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase not reported
Study design
OBSERVATIONAL
Evidence population
Human clinical study registration
Participants
300
Population
ALL · 60 Years
Duration
2023-09-28 to 2027-06-01
Intervention
Pegcetacoplan
Comparator
Not reported
Outcomes measured
Incidence of ocular AEs in treated eyes overall and according to physician-directed treatment interval based on US pres…; Incidence of other events of interest — Up to 36 months; Assess real-world treatment patterns and use of pegcetacoplan considering the proportion of participants with bilateral…; If only one eye is treated, the criteria for determination of the eye to be treated — Up to 36 months; The treatment interval (mean days between injections) over time — Up to 36 months; The frequency of imaging on treated eyes (color fundus photography, spectral domain optical coherence tomography [SD-OC…; The treatment adherence to planned dosing frequency: the number of injections administered divided by the number of inj…; The duration of persistence on treatment: continuous medication usage until a gap of ≥3 months — Up to 36 months; The treatment discontinuation and/or switching to other agents approved for treatment of GA — Up to 36 months; The management of new-onset exudative age-related macular degeneration (eAMD) events in eyes treated with pegcetacoplan…; The proportion of treated eyes that develop eAMD that receive anti-vascular endothelial growth factor (VEGF) injections…; The number of anti-VEGF injections per month from diagnosis of eAMD — Up to 36 months; The proportion of anti-VEGF injections given on same day in the same eye as pegcetacoplan — Up to 36 months
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase not reportedA trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Vision ageing · 100%Title contains controlled term: age-related macular degeneration. Abstract contains controlled term: age-related macular degeneration. Title supplies longevity context: age-related. Study type is explicitly identified as OBSERVATIONAL.

Automated source check 100% · update recency 100%. These figures help sort records; they are not medical ratings.