Clinical trial registry record

Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections

A registered PHASE4 study indexed because it matched monitored longevity research terms. Registry status: Enrolling By Invitation. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Enrolling By Invitation.
Evidence
Registered phase 4 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated April 7, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT07456826
Last registry update
April 7, 2026
Status
Enrolling By Invitation
Phase
Phase 4
Sponsor
Harrow Inc
Enrollment
236
Countries
United States
Match confidence
60%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE4 study indexed because it matched monitored longevity research terms. Registry status: Enrolling By Invitation. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 4
Study design
RANDOMIZED · PARALLEL · PREVENTION · DOUBLE
Evidence population
Human clinical study registration
Participants
236
Population
ALL · 18 Years
Duration
2026-03-31 to 2026-08-01
Intervention
Chloroprocaine Ophthalmic Gel 3% (IHEEZO); Sham Subconjunctival Injection; Proparacaine Hydrochloride Ophthalmic Solution 0.5%; Lidocaine Hydrochloride Injection 2%
Comparator
Routine Anesthesia (Proparacaine + Subconjunctival Lidocaine)
Outcomes measured
Proportion of Participants Achieving Successful Ocular Surface Anesthesia — Immediately before and immediately after in…; Pain Score Immediately Before Intravitreal Injection — Immediately before intravitreal injection (Day 1); Pain Score Immediately After Intravitreal Injection — Immediately after intravitreal injection (Day 1); Pain Score at Evening Follow-Up — Evening of Day 1 (3-12 hours post-injection); Pain Score at 24 Hours Post-Injection — Day 2 (20-28 hours post-injection); Cumulative 24-Hour Pain Score — Day 1 through 24 hours post-injection; Change From Baseline in SPEED Questionnaire Score — Baseline, Evening Day 1, and Day 2 (20-28 hours); Change in Best-Corrected Visual Acuity — Time Frame: Baseline and Day 7 ± 2 days; Change in Intraocular Pressure — Time Frame: Baseline and Day 7 ± 2 days; Corneal Fluorescein Staining Score — Time Frame: Baseline, post-injection Day 1, and Day 7 ± 2 days; Incidence of Treatment-Emergent Adverse Events — Time Frame: Day 1 through Day 7 ± 2 days Unit: Number of participants…
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 4A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 60% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Vision ageing · 60%Source terminology contains: age-related macular degeneration. Source terminology supplies longevity context: age-related. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 100%. These figures help sort records; they are not medical ratings.