Clinical trial registry record

Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT]

A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Active Not Recruiting.
Evidence
Registered phase not reported study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated February 10, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT04645212
Last registry update
February 10, 2026
Status
Active Not Recruiting
Phase
Phase not reported
Sponsor
Adverum Biotechnologies, Inc.
Enrollment
23
Countries
United States
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase not reported
Study design
OBSERVATIONAL
Evidence population
Human clinical study registration
Participants
23
Population
ALL · 50 Years
Duration
2020-12-14 to 2030-06-26
Intervention
ADVM-022
Comparator
Not reported
Outcomes measured
Severity and incidence of ocular and systemic adverse events (AEs). — 416 weeks (8 years); Mean change in best corrected visual acuity (BCVA) from baseline, over time — 416 weeks (8 years); Mean change in central subfield thickness (CST) and macular volume from baseline, over time — 416 weeks (8 years); Mean number of supplemental aflibercept injections over time — 416 weeks (8 years); Percentage of participants requiring supplemental bolus aflibercept over time — 416 weeks (8 years); Time to first supplemental aflibercept requirement — 416 weeks (8 years); Percentage of participants without intraretinal fluid (IRF) by spectral domain optical coherence tomography (SD-OCT), o…; Percentage of participants without subretinal fluid (SRF) by SD-OCT over time — 416 weeks (8 years); Time to first dry retina (defined as no IRF or SRF by SD-OCT) — 416 weeks (8 years); Duration of fluid free status (defined as no IRF or SRF by SD-OCT) — 416 weeks (8 years); Percentage of participants developing geographic atrophy over time (as assessed by multiple imaging modalities) — 416 w…; Growth of geographic atrophy over time, as assessed by multiple imaging modalities — 416 weeks (8 years); Percentage of participants with CST fluctuations > 50 μm over time — 416 weeks (8 years)
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase not reportedA trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Vision ageing · 100%Abstract contains controlled term: age-related macular degeneration. Source terminology contains: age-related macular degeneration. Abstract supplies longevity context: age-related. Study type is explicitly identified as OBSERVATIONAL.

Automated source check 100% · update recency 85%. These figures help sort records; they are not medical ratings.