Clinical trial registry record

Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD)

A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Completed.
Evidence
Registered phase 2 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated October 15, 2025.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT05381948
Last registry update
October 15, 2025
Status
Completed
Phase
Phase 2
Sponsor
EyePoint Pharmaceuticals, Inc.
Enrollment
161
Countries
United States
Match confidence
60%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 2
Study design
RANDOMIZED · PARALLEL · TREATMENT · TRIPLE
Evidence population
Human clinical study registration
Participants
161
Population
ALL · 50 Years
Duration
2022-06-30 to 2024-04-24
Intervention
EYP-1901; Aflibercept 2mg/0.05mL Inj,Oph
Comparator
Aflibercept
Outcomes measured
Average Change in Best Corrected Visual Acuity (BCVA) From Baseline Averaged Over Weeks 28 and 32 — Baseline (Day 1) an…; Change From Baseline in Best Corrected Visual Acuity up to Week 56 — Baseline (Day 1) and Weeks 32 and 56; Percentage of Subjects With >=5, >=10, and >=15 BCVA Letter Change From Baseline up to Week 56 — Baseline (Day 1) and W…; Percentage of Subjects Not Receiving Supplemental Injection of Aflibercept up to Week 56 — Weeks 32 and 56; Median Time to First Supplemental Aflibercept Injection in the Study Eye Following the EYP-1901 Dose at Week 8 — From W…; Number of Aflibercept Intravitreal Injections up to Week 56 (Including Loading Dose) — Weeks 32 and 56; Mean Change From Baseline in Central Subfield Thickness (CST) by Spectral-Domain - Optical Coherence Tomography (SD-OCT…; Change From Baseline in Height of Subretinal Fluid by Spectral-Domain - Optical Coherence Tomography up to Week 56 — Ba…; Percentage of Subjects With No Detectable Intraretinal Fluid/Cysts in the Central Subfield up to Week 56 — Weeks 32 and…; Change From Baseline in Total Lesion Area by Fluorescein Angiography (FA) up to Week 56 — Baseline (Day 1) and Weeks 32…; Change From Baseline in Total Choroidal Neovascularization Area by Fluorescein Angiography up to Week 56 — Baseline (Da…; Systemic Exposure to EYP-1901 Measured Through Plasma Levels up to Week 56 — Up to Week 56; Ocular Exposure to EYP-1901 Measured Through Aqueous Humor (AH) Levels up to Week 32 — Up to Week 32; Number of Subjects With Treatment-Emergent Adverse Events (TEAEs) and Serious Treatment-Emergent Adverse Events up to W…
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 2A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 60% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Vision ageing · 60%Source terminology contains: age-related macular degeneration. Source terminology supplies longevity context: age-related. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 85%. These figures help sort records; they are not medical ratings.