Clinical trial registry record

Safety and Efficacy of ADVM-022 in Treatment-Experienced Patients With Neovascular Age-related Macular Degeneration [LUNA]

A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Active Not Recruiting.
Evidence
Registered phase 2 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated August 22, 2025.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT05536973
Last registry update
August 22, 2025
Status
Active Not Recruiting
Phase
Phase 2
Sponsor
Adverum Biotechnologies, Inc.
Enrollment
69
Countries
United States, France, United Kingdom
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 2
Study design
RANDOMIZED · PARALLEL · TREATMENT · DOUBLE
Evidence population
Human clinical study registration
Participants
69
Population
ALL · 50 Years
Duration
2022-08-23 to 2028-08-01
Intervention
ADVM-022
Comparator
Not reported
Outcomes measured
Incidence of ocular and non-ocular adverse events — Up to Week 52; Severity of ocular and non-ocular adverse events — Up to Week 52; Mean change in best corrected visual acuity (BCVA) from Baseline — Baseline up to Week 52; Percentage of participants from Baseline who lose/gain at least 5, 10 or 15 letters in BCVA — Baseline up to 5 years; Mean change in BCVA from Baseline — Baseline up to 5 years; Percentage of participants who are supplemental aflibercept injection-free — Baseline up to 5 years; Percent reduction in annualized anti-VEGF injections — Baseline up to 5 years; Mean change in Central Subfield Thickness (CST) from Baseline — Baseline up to 5 years; Percentage of participants without CST fluctuations — Baseline up to 5 years; Mean number of CST fluctuations from Baseline — Baseline up to 5 years; Percentage of participants without post-prophylactic inflammation — Baseline up to 5 years; Incidence of ocular and non-ocular adverse events — Up to 60 months; Severity of ocular and non-ocular adverse events — Up to 60 months
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 2A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Vision ageing · 100%Title contains controlled term: age-related macular degeneration. Abstract contains controlled term: age-related macular degeneration. Source terminology contains: age-related macular degeneration. Title supplies longevity context: age-related. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 65%. These figures help sort records; they are not medical ratings.