Clinical trial registry record

Study of Brolucizumab in Adult Patients With Suboptimal Anatomically Controlled Neovascular Age-related Macular Degeneration

A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Completed.
Evidence
Registered phase 3 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated November 7, 2024.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT04264819
Last registry update
November 7, 2024
Status
Completed
Phase
Phase 3
Sponsor
Novartis Pharmaceuticals
Enrollment
295
Countries
France
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 3
Study design
NA · SINGLE GROUP · TREATMENT · NONE
Evidence population
Human clinical study registration
Participants
295
Population
ALL · 50 Years
Duration
2020-12-14 to 2023-05-10
Intervention
RTH258/Brolucizumab
Comparator
Not reported
Outcomes measured
Number of Patients With no Disease Activity at Week 16 in the Study Eye — Week 16; Number of Patients With no Disease Activity at Week 48 in the Study Eye — Week 48; Change From Baseline in CFST (Central Sub-Field Retinal Thickness) as Assessed by OCT (Optical Coherence Tomography) Ov…; Absence of IRF (Intraretinal Fluid), SRF (Subretinal Fluid), and Sub-RPE (Retinal Pigmented Epithelium) Fluid as Assess…; Number of Patients With a Dry Retina (Neither IRF Nor SRF) up to Week 48 in the Study Eye — Baseline, Weeks 4, 8, 16, 48; Distribution of the Last Interval With no Disease Activity up to Week 48 in the Study Eye — Intervals of 0,4,5,6,7,8,9,…; Distribution of the Maximal Intervals With no Disease Activity up to Week 48 in the Study Eye — Intervals of 0,4,5,6,7,…; Average Change in BCVA (Best-Corrected Visual Acuity) From Baseline up to Week 48 in the Study Eye — Baseline, Weeks 4,…; Summary of Treatment-emergent Adverse Events - Overall — Adverse events were reported from first dose of study treatmen…; Summary of Treatment-emergent Adverse Events Regardless of Study Treatment Relationship by Primary System Organ Class,…
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 3A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Vision ageing · 100%Title contains controlled term: age-related macular degeneration. Abstract contains controlled term: age-related macular degeneration. Source terminology contains: age-related macular degeneration. Title supplies longevity context: age-related. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 65%. These figures help sort records; they are not medical ratings.