Clinical trial registry record

Targeting Aging With a Ketone Ester for Function in Frailty

A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Recruiting.
Evidence
Registered phase not reported study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated September 9, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT06645847
Last registry update
September 9, 2026
Status
Recruiting
Phase
Phase not reported
Sponsor
Buck Institute for Research on Aging
Enrollment
180
Countries
United States
Match confidence
80%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase not reported
Study design
RANDOMIZED · PARALLEL · BASIC SCIENCE · QUADRUPLE
Evidence population
Human clinical study registration
Participants
180
Population
ALL · 65 Years
Duration
2025-04-17 to 2028-04-01
Intervention
Ketone ester; Placebo Comparator: Non-ketone placebo
Comparator
Ketone ester; Non-ketone placebo
Outcomes measured
Frailty composite score — Baseline, 12 weeks, 20 weeks; Tolerability key symptom index — 20 weeks; Safety Lab Tests — Baseline, Week 4, Week 12, 20 weeks; Leg fatigue - leg press at sub maximal weight — 20 weeks; Short Physical Performance Battery — Baseline, Week 12, 20 weeks; Grip Strength — Baseline, Week 12, Week 20; Montreal Cognitive Assessment — Baseline, 12 weeks, 20 weeks; Trails A and B — Baseline, Week 12, Week 20
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase not reportedA trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 80% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Frailty · 80%Title contains controlled term: frailty. Title supplies longevity context: aging, frailty. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 100%. These figures help sort records; they are not medical ratings.

frailty
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