Clinical trial registry record

A clinical trial investigating the use of a drug called metformin as a way of reducing the cancer risk in people with Li Fraumeni Syndrome (LFS)

A registered Phase II study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Recruiting.
Evidence
Registered phase ii study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated June 3, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
ISRCTN16699730
Last registry update
June 3, 2026
Status
Recruiting
Phase
Phase II
Sponsor
University of Oxford
Enrollment
0
Countries
United Kingdom, England, Scotland
Match confidence
100%
Source feed
ISRCTN Registry
Automated source synopsis

A registered Phase II study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase II
Study design
Interventional
Evidence population
Human clinical study registration
Participants
0
Population
All · Mixed
Duration
2023-12-20 to 2030-12-31
Intervention
Metformin; Drug
Comparator
Not reported
Outcomes measured
Cancer free survival – with “cancer” event defined as pathologically confirmed diagnosis of malignant cancer identified…; 1. Tumour free survival – with a “tumour” event including pathologically confirmed diagnosis of malignant cancer or cli…
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase IIA trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Metformin · 100%Title contains controlled topic terminology. Summary contains controlled topic terminology. Source terminology contains a controlled topic term.

Automated source check 98% · update recency 100%. These figures help sort records; they are not medical ratings.

metformin
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