Clinical trial registry record

Diabetes Prevention Program Outcomes Study

A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Completed.
Evidence
Registered phase 3 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated July 30, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT00038727
Last registry update
July 30, 2026
Status
Completed
Phase
Phase 3
Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Enrollment
2779
Countries
United States
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase 3
Study design
RANDOMIZED · PARALLEL · PREVENTION · NONE
Evidence population
Human clinical study registration
Participants
2779
Population
ALL · 25 Years
Duration
1996-07-31 to 2022-04-30
Intervention
DPPOS Group Lifestyle; Metformin; DPPOS Boost Lifestyle; Intensive Lifestyle Group Session
Comparator
1 Original Lifestyle; 2 Original Metformin; 3 Original Placebo
Outcomes measured
Number of Participants With Diabetes. — Outcomes were assessed from 1996-2020 for median follow-up of 21 years and a ma…; Prevalence of Aggregate Microvascular Complication — Outcomes were assessed from 2012-2013 (approximately 2 years).; Number of Participants With Total Cancer Except Non-melanoma Skin Cancer — Outcomes were assessed from 1996-2020 (appro…; Number of Participants With Major Adverse Cardiovascular Events (MACE): Myocardial Infarction (MI), Stroke, or Cardiova…; Subclinical Atherosclerosis — Outcomes were assessed from 2012-2013 (approximately 2 years).; Cognitive Function — Outcomes were assessed in visit year 8 starting in 2010; Short Physical Performance Battery — Outcomes were assessed in visit years 8, 10 , and 15 which started in 2010, 2012,…; Frailty — Outcomes were assessed in DPPOS Visits years 8, 10 and 15 which started in 2010, 2012, and 2017; Mortality — Outcomes were assessed throughout follow-up from 1996 to 2019. National Death Index search conducted in 201…
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase 3A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Metformin · 100%Abstract contains controlled term: metformin. Source terminology contains: metformin. Abstract supplies longevity context: aging. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 100%. These figures help sort records; they are not medical ratings.

metformin
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