Clinical trial registry record

Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study

A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Completed.
Evidence
Registered early phase 1 study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated March 4, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT03617302
Last registry update
March 4, 2026
Status
Completed
Phase
EARLY Phase 1
Sponsor
Gary L. Pierce, PhD
Enrollment
16
Countries
United States
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
EARLY Phase 1
Study design
RANDOMIZED · CROSSOVER · TREATMENT · DOUBLE
Evidence population
Human clinical study registration
Participants
16
Population
ALL · 50 Years to 79 Years
Duration
2018-11-01 to 2024-06-30
Intervention
Experimental: Nitrate-containing; Placebo: Nitrate-depleted
Comparator
Beetroot juice; Placebo Beetroot juice
Outcomes measured
Change in Carotid Artery Compliance in mm/mmHg x 10-1 — Baseline and 2 hours following nitrate-depleted placebo beetroo…; Change in Carotid Augmentation Index — Baseline and 2 hours following nitrate-depleted beetroot juice or nitrate-contai…; Change in Carotid Pulse Pressure in mmHg — Baseline and 2 hours following nitrate-depleted beetroot juice or nitrate-co…
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · EARLY Phase 1A trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Cardiovascular ageing · 100%Title contains controlled term: vascular aging, arterial stiffness. Source terminology contains: arterial stiffness. Title supplies longevity context: aging. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 85%. These figures help sort records; they are not medical ratings.

cardiovascular aging
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