Clinical trial registry record

Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated to Longevity in Pre-frail Adults

A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Recruiting.
Evidence
Registered phase not reported study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated March 6, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT07454616
Last registry update
March 6, 2026
Status
Recruiting
Phase
Phase not reported
Sponsor
National University of Singapore
Enrollment
40
Countries
Singapore
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase not reported
Study design
NA · SINGLE GROUP · HEALTH SERVICES RESEARCH · NONE
Evidence population
Human clinical study registration
Participants
40
Population
ALL · 50 Years to 80 Years
Duration
2025-09-22 to 2026-05-08
Intervention
Supervised exercise program; a balanced micronutrient blend
Comparator
Not reported
Outcomes measured
Change in muscle mass measured via B- mode ultrasound — Baseline and 12 weeks; Change on Fecal Bifidobacterium level measured via stool microbiome analysis — Baseline, 6 weeks and 12 weeks; Change in cognitive performance National Institutes of Health Toolbox Cognition Battery - Fluid composite — Baseline an…; Change in the immune function (CD4+: CD8+ ratio) — Baseline, 6 weeks and 12 weeks; Change in cardiorespiratory fitness (Peak VO₂) — Baseline and 12 weeks; Change in Muscle Strength assessed using 1RM strength test — Baseline and 12 weeks; Change in Handgrip Strength Measured by Dynamometer — Baseline, 6 weeks and 12 weeks; Stool consistency, frequency and gastrointestinal tolerance — baseline, 12 weeks; Change in Biological age determined by DNAm clocks — baseline, 12 weeks; Change in advanced glycation end-products (AGEs) assessed using skin autofluorescence. — Baseline, 12 weeks; Change in inflammatory markers (IL-6, IL-10, TNF-α and IFN-γ) — Baseline, 6 weeks and 12 weeks; Change in immune function as measured by Lymphocyte/neutrophil ratio — Baseline, 6 weeks and 12 weeks; Change in blood pressure measured using SphygmoCor-XCEL — baseline, 6 weeks, 12 weeks; Change in Arterial stiffness measured via SphygmoCor-XCEL — Baseline and 12 weeks; Change in Physical Activity Levels Measured by Wearable Devices — baseline, 12 weeks; Change in heart rate measured with SphygmoCor-XCEL — Baseline, 6 weeks and 12 weeks; Change in Lean Mass measured by Dual-Energy X-ray Absorptiometry (DXA) — Baseline and 12 weeks; Change in Body Composition Measured by Bioimpedance (InBody 770) — Baseline and 12 weeks; Change in Quality of life assessed by The 36-Item Short Form Health Survey questionnaire (SF-36) — baseline, 12 weeks; Change in Quality of Life Measured by EuroQol 5-Dimensions (EQ-5D) — Baseline, 12 weeks
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase not reportedA trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Exercise · 100%Title contains controlled term: exercise. Abstract contains controlled term: exercise. Source terminology contains: exercise. Title supplies longevity context: longevity, frail. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 85%. These figures help sort records; they are not medical ratings.