Clinical trial registry record

Can metformin prevent worsening of muscle weakness and frailty in older people who are showing early signs of frailty?

A registered Phase IV study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Completed.
Evidence
Registered phase iv study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated April 28, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
ISRCTN29932357
Last registry update
April 28, 2026
Status
Completed
Phase
Phase IV
Sponsor
Newcastle upon Tyne Hospitals NHS Foundation Trust
Enrollment
72
Countries
United Kingdom, England
Match confidence
100%
Source feed
ISRCTN Registry
Automated source synopsis

A registered Phase IV study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase IV
Study design
Interventional
Evidence population
Human clinical study registration
Participants
72
Population
All · Senior
Duration
2021-04-01 to 2023-08-31
Intervention
Metformin hydrochloride; Drug
Comparator
Not reported
Outcomes measured
4-m walk speed at 4 months; 1. Fried frailty score, including individual components: 1.1. Activity level assessed using self-report questionnaire a…
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase IVA trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Metformin · 100%Title contains controlled term: metformin. Abstract contains controlled term: metformin. Source terminology contains: metformin. Title supplies longevity context: frailty, frail. Study type is explicitly identified as Interventional.

Automated source check 98% · update recency 100%. These figures help sort records; they are not medical ratings.

metformin
Open primary sourceExport JSON