Clinical trial registry record

Involvement of Muscle Mitochondrial Dysfunction in Frailty in Older Adults. Role of Exercise

A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Plain-language guide

Five questions to ask about this record

What this is
A clinical study registration, not a result or recommendation.
Why it may matter
The registry currently reports Recruiting.
Evidence
Registered phase not reported study.
Main limitation
Registration does not prove that the intervention works, is safe, or is available to you.
What changed
Registry metadata was last updated September 18, 2026.
Where to verify
Open the primary registry below for eligibility, locations, contacts, and current status.
Registry ID
NCT07828847
Last registry update
September 18, 2026
Status
Recruiting
Phase
Phase not reported
Sponsor
Fundación para la Investigación del Hospital Clínico de Valencia
Enrollment
120
Countries
Spain
Match confidence
100%
Source feed
ClinicalTrials.gov
Automated source synopsis

A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.

Evidence snapshot

What the source actually supports

Evidence stage
Phase not reported
Study design
NON RANDOMIZED · PARALLEL · TREATMENT · SINGLE
Evidence population
Human clinical study registration
Participants
120
Population
ALL · 18 Years to 83 Years
Duration
2022-01-29 to 2028-07-31
Intervention
Short-duration resistance training
Comparator
Group of healthy trained old people; Group of type 2 diabetic trained old patients; Group of healthy trained young people
Outcomes measured
Change in Mitochondrial Oxidative Phosphorylation (OXPHOS) Capacity in Skeletal Muscle — Baseline and after 6 weeks of…; Change in Mitochondrial Oxidative Phosphorylation (OXPHOS) Capacity in Peripheral Blood Mononuclear Cells (PBMCs) — Bas…; Change in Mitochondrial Quality Control Protein Expression in Skeletal Muscle — Baseline and after 6 weeks of supervise…; Change in Whole-Body Lean Mass — Baseline and after 6 weeks of supervised resistance training; Change in Whole-Body Fat Mass — Baseline and after 6 weeks of supervised resistance training; Change in 6-Minute Walk Test Distance — Baseline and after 6 weeks of supervised resistance training; Change in Blood Glucose-6-Phosphate Dehydrogenase (G6PD) Activity — Baseline and after 6 weeks of supervised resistance…; Change in Skeletal Muscle Cell-Type-Specific Transcriptomic Profiles — Baseline and after 6 weeks of supervised resista…; Change in Gut Microbiota Alpha Diversity — Baseline and after 6 weeks of supervised resistance training; Change in Quadriceps Muscle Thickness — Baseline and after 6 weeks of supervised resistance training; Change in Skeletal Muscle Fibre Cross-Sectional Area — Baseline and after 6 weeks of supervised resistance training; Change in Short Physical Performance Battery (SPPB) Score — Baseline and after 6 weeks of supervised resistance training; Change in FallSkip Test Performance Time — Baseline and after 6 weeks of supervised resistance training; Change in Blood Malondialdehyde (MDA) Levels — Baseline and after 6 weeks of supervised resistance training; Change in Fried Frailty Phenotype Score — Baseline and after 6 weeks of supervised resistance training; Change in Frailty Classification Assessed by the Survey of Health, Ageing and Retirement in Europe Frailty Instrument (…; Change in Quadriceps Extension 3-Repetition Maximum (3RM) — Baseline and after 6 weeks of supervised resistance training; Change in Skeletal Muscle Chromatin Accessibility Profiles Assessed by ATAC-seq — Baseline and after 6 weeks of supervi…; Change in Plasma Proteomic Profiles — Baseline and after 6 weeks of supervised resistance training
Reported result
No reusable finding-level result is available in this record.

Main limitationThis is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.

Safety and approvalEligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians. Trial registration is not regulatory approval and does not establish that an intervention is available.

Source supportStructured registry protocol metadata; no finding-level conclusion is generated.

Trial stage · Phase not reportedA trial phase describes development stage; it does not establish a positive result.
Phase 1Phase 2Phase 3Phase 4

Registration and recruitment status do not establish safety, efficacy, or regulatory approval.

Why this record appears here · 100% topic match

The title, summary, or source keywords matched one or more topics followed by immortal.life. A higher percentage means a stronger topic match; it does not rate safety, effectiveness, or study quality.

  • Exercise · 100%Title contains controlled term: exercise. Abstract contains controlled term: physical activity. Title supplies longevity context: frailty, frail. Study type is explicitly identified as INTERVENTIONAL.
  • Frailty · 100%Title contains controlled term: frailty. Abstract contains controlled term: frailty. Title supplies longevity context: frailty, frail. Study type is explicitly identified as INTERVENTIONAL.
  • Mitochondrial function · 100%Title contains controlled term: mitochondrial dysfunction. Abstract contains controlled term: mitochondrial dysfunction, mitochondrial function. Source terminology contains: mitochondrial function. Title supplies longevity context: frailty, frail. Study type is explicitly identified as INTERVENTIONAL.

Automated source check 100% · update recency 100%. These figures help sort records; they are not medical ratings.

exercisefrailtymitochondrial function
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