Berberine
A familiar starting point. A wider world of research.
Follow berberine through source-linked records, connected to Senolytics and Cancer and ageing. Explore the connections, then open the original evidence.
Explore the evidenceUnexpected company.
A selection of other objects mentioned in these records. Inspect the shared source to see the connection; a shared mention does not mean the same effect.
Oxidative stress
Inspect supporting records 9Autophagy
Inspect supporting records 3astaxanthin
Inspect supporting records 2fisetin
Inspect supporting records 2cigarette smoking
Inspect supporting records 1curcumin
Inspect supporting records 1More connections in this selection
flavonoids
Inspect supporting records 1glucosamine
Inspect supporting records 1ionizing radiation
Inspect supporting records 1melatonin
Inspect supporting records 1Mitochondrial function
Inspect supporting records 1polyphenols
Inspect supporting records 1Proteostasis
Inspect supporting records 1resveratrol
Inspect supporting records 1selenium
Inspect supporting records 1Senescence-associated secretory phenotype
Inspect supporting records 1spermidine
Inspect supporting records 1taurine
Inspect supporting records 1urolithin a
Inspect supporting records 1Where the research leads.
Published topic links attached to the selected records. Each dossier opens a wider field, including its own research ecosystem.
- SenolyticsRecords in this selection 11
- Cancer and ageingRecords in this selection 3
- Mitochondrial functionRecords in this selection 3
- Nutrient sensingRecords in this selection 3
- Oxidative stressRecords in this selection 3
- SirtuinsRecords in this selection 3
- AutophagyRecords in this selection 1
- Chronic inflammationRecords in this selection 1
- Cognitive ageingRecords in this selection 1
- CryobiologyRecords in this selection 1
- FisetinRecords in this selection 1
- Genomic instabilityRecords in this selection 1
- Heart ageingRecords in this selection 1
- MetforminRecords in this selection 1
- RapamycinRecords in this selection 1
- ResveratrolRecords in this selection 1
- Senescence-associated secretory phenotypeRecords in this selection 1
- SpermidineRecords in this selection 1
- Stem cellsRecords in this selection 1
- TaurineRecords in this selection 1
- Telomeres and telomeraseRecords in this selection 1
- Urolithin ARecords in this selection 1
- Vision ageingRecords in this selection 1
Meet the wider research ecosystem.
Follow a connected field into its universities, funding and patent activity.
University, grant and patent activity in a topic dossier concerns that wider field; it is not a berberine-specific total.
Different records. Different questions.
This is the composition of the initial 24-record selection, not the entire collection. Open a group to inspect its supporting records. Publication types and existing automated evidence labels describe records, not their quality or conclusions. Unclassified records remain in “Other research records”.
News and commentary are shown separately from study and review records.
The recent trail.
Recent sources in this selection: publication months for publications, registry update months for registrations.
Good questions to bring along.
What can I learn about berberine here?
See which permitted records mention this object, follow the topics and other objects connected through those records, and inspect the sources. Whole foods, preparations, extracts and isolated compounds keep separate identities.
Do these records establish a benefit?
A mention is a starting point for discovery. Open each original source to assess the study design, population, findings and limitations. A trial registration describes planned or registered work; it is not itself a result.
How can I compare related objects?
Open a connected object and compare the actual records, preparations and research settings. “Mentioned in the same record” explains a navigation link; it does not establish equivalence, composition or causality.
How complete is this picture?
This is the current eligible selection from the immortal.life index; use Show more records to continue browsing. Missing records or classifications do not prove that research is absent. Source permissions and corrections can change the selection.
Open the evidence.
Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP.
Natural Bioactive Compounds Targeting Key Hallmarks of Aging: Functional Food Potential of Spermidine, Fisetin, Berberine, and Urolithin A.
Demethyleneberberine alleviates cellular senescence of human fibroblasts by directly activating FEN1.
A Novel Mechanism of Berberine Targeting EIF2AK2 Dimerization Attenuates Methylglyoxal-Induced Endothelial Senescence and Apoptosis.
M6PR upregulation by berberine attenuates hepatic senescence via sorting STING into endosome for degradation.
Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes.
Taurine and Berberine: Nutritional Interventions Targeting Cellular Mechanisms of Aging and Longevity.
Berberine Derivative B68 Promotes Tumor Immune Clearance by Dual-Targeting BMI1 for Senescence Induction and CSN5 for PD-L1 Degradation.
Effects of nano-berberine and berberine loaded on green synthesized selenium nanoparticles on cryopreservation and in vitro fertilization of goat sperm.
Berberine attenuates brain aging via stabilizing redox homeostasis and inflammation in an accelerated senescence model of Wistar rats.
Berberine may provide redox homeostasis during aging in rats.
Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy.
Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway.
Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration.
Attenuation of Cigarette-Smoke-Induced Oxidative Stress, Senescence, and Inflammation by Berberine-Loaded Liquid Crystalline Nanoparticles: In Vitro Study in 16HBE and RAW264.7 Cells.
Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc/HIF-1α pathway.
Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence.
Astaxanthin plus berberine: a nutraceutical strategy for replicating the benefits of a metformin/fibrate regimen in metabolic syndrome.
Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats.
Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation.
The Preconditioning of Berberine Suppresses Hydrogen Peroxide-Induced Premature Senescence via Regulation of Sirtuin 1.
Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs.
A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region.
Berberine induces senescence of human glioblastoma cells by downregulating the EGFR-MEK-ERK signaling pathway.
About this collection: scope and limitations
Nutrient or compound · Compound identity, formulation and the studied outcome matter. A record about a related substance, a product or a mechanism does not automatically apply to this identity.
Questions to check in the original studies
- Which compound and formulation does the source identify?
- Which population and outcome were studied?
- Is an observation about a measured outcome being distinguished from a claim about ageing or lifespan?
What the displayed selection contains
24 research metadata records and 0 trial registrations were returned in the initial selection. More records can be loaded above. This is not a complete worldwide evidence review. These counts do not measure benefit, safety or evidence certainty.
Interpretation remains unassessed
Open the original sources to assess study design, findings and applicability. A trial registration is not a result; a metadata mention is not a scientific conclusion. Missing matches do not establish that research is absent.
Index snapshot: . This is the index projection timestamp, not the date of a discovery or expert review.
Cite this research-navigation view
immortal.life. berberine: research mentions. https://www.immortal.life/explore/berberine. Projection snapshot: 2026-10-10T11:22:04.770Z.
Include your access date. This citation identifies an automated navigation view, not a clinical conclusion. The live selection can change with corrections and source permissions.
Matching, coverage and vocabulary provenance
This automated index uses permitted minimal bibliographic metadata and checks current source and record eligibility. Literal title or controlled-term matches are discovery relationships, not scientific findings. Retained metadata coverage is bounded; historical completeness of external sources is not certified.
Foods, preparations, extracts and compounds retain distinct identities. Ambiguous labels require a choice. Source AI processing, model training and raw redistribution are disabled for this search.
Vocabulary attribution: FoodOn contributors, CC BY 4.0, filtered own-namespace labels/IDs and references; courtesy of the U.S. National Library of Medicine, 2026 MeSH vocabulary terms, filtered labels/entry terms; USDA FoodData Central, Foundation Foods April 2026, CC0, filtered identifiers/descriptions. No source endorsement. Navigation spelling/plural changes are separately attributed.