September 14, 2026 — September 20, 2026

Longevity evidence briefing · 2026-09-14

389 newly indexed source records for the week ending 2026-09-20.

The automated index added 251 research records, 138 clinical trial records, 0 regulatory notices, and 0 research-integrity events. Counts reflect ingestion activity, not evidence strength or clinical importance.

Research

  1. Age-dependent genetic effects contribute to immunosenescence in Drosophila melanogaster.
  2. Zuogui Pill alleviates chemotherapy-induced ovarian aging and oogonial stem cell injury by modulating cGAS-STING-mediated inflammatory signaling.
  3. Schisandra chinensis Modulates Cellular Senescence through Integrated Regulation of Redox, Mitochondrial, and Inflammatory Homeostasis.
  4. A New Omics View of Retinal Aging: Cell-Type Vulnerability, Spatial Niches, and Disease Susceptibility.
  5. Chronic low-grade inflammation drives skeletal aging and neurocognitive decline: inflammaging as a central hub coupling bone-brain aging.
  6. Targeted structural destabilization of flavonoids: A novel paradigm for metabolic reprogramming and anti-senescence to repair the alveolar-capillary barrier.
  7. Evaluation the role of quinoa seeds in attenuation the brain cellular senescence and aging induced by D-galactose and γ-radiation in rats: insights into autophagy, telomerase activity, amyloid-β and tau proteins.
  8. Validation and refinement of a biomarker panel for frailty assessment and prediction of muscle weakness in older adults.
  9. Platelet peptidylarginine deiminase 4 is not essential for platelet function in homeostasis or fibrosis during normal aging.
  10. Necroptosis-senescence crosstalk in tubulointerstitial fibrosis: the mtDNA-cGAS-STING-PFKFB3 axis as a metabolic bridge.
  11. Cellular senescence is an early feature and therapeutic target in amyotrophic lateral sclerosis TDP-43<sup>Q331K</sup> mice.
  12. Senescence-associated extracellular vesicles in skin aging and regeneration: from pathophysiology to therapeutic opportunities.
  13. A miR-10a-5p-γCaMKII axis links periphery-to-brain signaling to cognitive vulnerability during female midlife.
  14. Rapamycin in Frail Older Subjects with Heart Failure with Preserved Ejection Fraction.
  15. Lifelong caloric restriction reshapes age-related hepatic oxylipin profiles and is associated with a CYB5R3-linked epoxide-diol signature.
  16. Effect of manual diaphragmatic release technique on exercise capacity and sleep quality in older adults with Type II diabetes: A randomized controlled trial.
  17. Age-Related Transitions in Low Back Pain Pathology: A Life-Course Narrative Review.
  18. Maternal metformin treatment in obese pregnant dams normalizes neonatal sensory-motor reflexes
  19. Editorial: Oral health and successful aging: integrating basic research, clinical insights and community health
  20. Lymphatic-Immune Microenvironment Engineering via Rapamycin-Eluting Nanofibers for Meningeal Repair and Neuroprotection in Traumatic Brain Injury Rats.
  21. Necroptosis–senescence crosstalk in tubulointerstitial fibrosis: the mtDNA–cGAS–STING–PFKFB3 axis as a metabolic bridge
  22. DNA methylation variability provides a complementary epigenetic signature of aging heterogeneity: Findings from the Canadian Longitudinal Study on Aging and the Baltimore Longitudinal Study of Aging.
  23. Divergent Retrograde Signaling Pathways Coordinate Longevity and Metformin Responses in Complex I and Complex IV Deficient C. elegans
  24. A Polyphenolic Compound Amelirotates Mitochondrial Dysfunction in Human Cardiomyocyte Like Cells Subjected to Insulin-Resistant Senescence or β-Adrenergic Stress
  25. Mitochondrial dysfunction and impaired osteogenic capacity define stress-induced osteoblast senescence

Trials

  1. Immune Aging and Advanced Therapy Outcomes in Older Adults With IBD
  2. Involvement of Muscle Mitochondrial Dysfunction in Frailty in Older Adults. Role of Exercise
  3. A Frailty-specific Prehabilitation Program for Mild to Moderately Frail Patients Undergoing Cardiac Surgeries/Procedures
  4. Muscle Aging Phenotypes in Childhood Cancer Survivors
  5. Motivational Support for an Autonomous Exercise Program for Healthy Aging
  6. Effectiveness of a Socio-Community Health Intervention on Pre-Frailty in Older Adults
  7. Evaluation of the Efficacy of Calcium a -Ketoglutarate(AKG-Ca) in Improving Human Aging
  8. A Nutritional and Pharmacological Intervention for Body, Brain, and Longevity Effects (NIBBLE)
  9. The Longitudinal Evaluation of Ovarian Aging and Cardiovascular Risk
  10. Sirolimus Treatment in Pediatric Patients With Ataxia-Telangiectasia
  11. The Effect of Oral SPM Supplementation on INflammation-induced Vascular Ageing in Obese Hypertensive Patients
  12. Urban Exposome and Biological Age
  13. In-Person, Online, and Hybrid Healthy-Aging Education for Pre-Frailty and Frailty in Older Adults
  14. Physical Activity and Healthy Aging: Promoting Cardio-metabolic Capacity to Fight Chronic Inflammation and Improve Outcomes in Breast Cancer Patients (PhActHealth Study)
  15. Tocotrienol Supplementa as A Senolytic Agent in Middle-aged Adults
  16. More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)
  17. Frailty and Dysphagia in Older Adults
  18. Nurse-Led Caregiver Support for Older Adults With Advanced Lung Cancer
  19. Effects of Miricell Supplementation on Biomarkers of Healthy Aging and Autophagy
  20. Safety, Efficacy of FFP From Healthy Donors to Ameliorate Frailty and Enhance Immune Function in Older Individuals
  21. Creating Stem Cells From a Progeria Patient's Blood to Test Candidate Treatments in the Lab
  22. A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration
  23. Effects of Plasmapheresis on Aging Biomarkers
  24. Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment
  25. Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults

Regulatory

No newly indexed records in this category.

Integrity

No newly indexed records in this category.